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The rats of two groups received a single intraperitoneal administration of 30 mg\/kg ketamine and 30 mg\/kg rhynchophylline, respectively, and the third group received combined intraperitoneal administration of 30 mg\/kg ketamine and 30 mg\/kg rhynchophylline together. After blood sampling at different time points and processing, the concentrations of ketamine and rhynchophylline in rat plasma were determined by the established ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS\/MS) method. Chromatographic separation was achieved using a UPLC BEH C18 column (2.1 mm \u00d7 50 mm, 1.7<jats:italic>\u03bc<\/jats:italic>m) with carbamazepine as an internal standard (IS). The initial mobile phase consisted of acetonitrile and water (containing 0.1% formic acid) with gradient elution. Multiple reaction monitoring (MRM) modes of<jats:italic>m\/z<\/jats:italic>238.1 \u2192 179.1 for ketamine,<jats:italic>m\/z<\/jats:italic>385.3 \u2192 159.8 for rhynchophylline, and<jats:italic>m\/z<\/jats:italic>237.3 \u2192 194.3 for carbamazepine (IS) were utilized to conduct quantitative analysis. Calibration curve of ketamine and rhynchophylline in rat plasma demonstrated good linearity in the range of 1-1000 ng\/mL (r &gt; 0.995), and the lower limit of quantification (LLOQ) was 1 ng\/mL. Moreover, the intra- and interday precision relative standard deviation (RSD) of ketamine and rhynchophylline were less than 11% and 14%, respectively. This sensitive, rapid, and selective UPLC-MS\/MS method was successfully applied to pharmacokinetic interaction study of ketamine and rhynchophylline after intraperitoneal administration. The results showed that there may be a reciprocal inhibition between ketamine and rhynchophylline.<\/jats:p>","DOI":"10.1155\/2018\/6562309","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T19:31:43Z","timestamp":1527103903000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry"],"prefix":"10.1155","volume":"2018","author":[{"given":"Lianguo","family":"Chen","sequence":"first","affiliation":[{"name":"The Third Clinical Institute Affiliated to Wenzhou Medical University & Wenzhou People\u2019s Hospital, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"You","sequence":"additional","affiliation":[{"name":"The Third Clinical Institute Affiliated to Wenzhou Medical University & Wenzhou People\u2019s Hospital, Wenzhou 325000, 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