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Female Wistar rats underwent surgical ovariectomy (OVX) or sham operation (SO) and were then divided into eight subgroups based on the type of diet (standard chow or high\u2010triglyceride diet\/HT) and exercise (with or without running). After 12 weeks, cardiac MMP\u20102 activity, tissue inhibitor of metalloproteinase\u20102, content of collagen type I, the level of nitrotyrosine (3\u2010NT) and glutathione (GSH), and the ratio of infarct size were determined. Our results show that OVX and HT diet caused an excessive accumulation of collagen; however, this increase was not observed in the trained animals. Twelve weeks of exercise promoted elevation in the levels of 3\u2010NT and GSH and similarly an increase in MMP\u20102 activity of both SO and OVX animals. The high infarct\u2010size ratio caused by OVX and HT diet was mitigated by physical exercise. Our findings demonstrate that ovarian estrogen loss and HT diet caused collagen accumulation and increased ratio of the infarct size. However, exercise\u2010induced cardiac remodeling serves as a compensatory mechanism by enhancing MMP\u20102 activity and reducing fibrosis, thus minimizing the ischemia\/reperfusion injury.<\/jats:p>","DOI":"10.1155\/2018\/6709742","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T23:34:15Z","timestamp":1518564855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of Exercise\u2010Induced Cardiac Remodeling in Ovariectomized Female 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