{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:45:51Z","timestamp":1740159951916,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis Research and Treatment"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube\u00ae (QFT) results in some participants. The purpose of the current study was to investigate whether the interferon-gamma (IFN-<jats:italic>\u03b3<\/jats:italic>) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy.<jats:italic>Methods.<\/jats:italic>The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae and QFT, compared to the tuberculin skin test (TST) for the serial testing of TBI in HCW at 4 US sites. Unstimulated plasma from 9 discordant TO18 participants at 4 different time points from the Houston site was multiplexed to determine the association between circulating cytokines and antigen stimulated IFN-<jats:italic>\u03b3<\/jats:italic>levels.<jats:italic>Results.<\/jats:italic>IL-12, IL-1<jats:italic>\u03b2<\/jats:italic>, IL-3, GCSF, and IL-7 were associated with the amount of IFN-<jats:italic>\u03b3<\/jats:italic>measured in response to antigen stimulation. In addition to these cytokines, a significant relationship was found between a positive QFT result and the spring season.<jats:italic>Conclusions.<\/jats:italic>Allergens during the spring season can result in the upregulation of IL-1<jats:italic>\u03b2<\/jats:italic>and IL-3, and this upregulation was observed with the amount of IFN-<jats:italic>\u03b3<\/jats:italic>measured in discordant results.<\/jats:p>","DOI":"10.1155\/2018\/6731207","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T23:30:55Z","timestamp":1520897455000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances"],"prefix":"10.1155","volume":"2018","author":[{"given":"Marsha L.","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-0926","authenticated-orcid":true,"given":"Saroochi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Zhu","family":"Murphy","sequence":"additional","affiliation":[{"name":"Paul L. 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