{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:54:11Z","timestamp":1761519251943,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"],"award-info":[{"award-number":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"],"award-info":[{"award-number":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"],"award-info":[{"award-number":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"],"award-info":[{"award-number":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CERNET Next Generation Internet Technology Innovation Project","award":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"],"award-info":[{"award-number":["2018JJ4058","2017JJ5036","61640210","61672447","NGII20160305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Motivation<\/jats:italic>. Increasing studies have demonstrated that many human complex diseases are associated with not only microRNAs, but also long-noncoding RNAs (lncRNAs). LncRNAs and microRNA play significant roles in various biological processes. Therefore, developing effective computational models for predicting novel associations between diseases and lncRNA-miRNA pairs (LMPairs) will be beneficial to not only the understanding of disease mechanisms at lncRNA-miRNA level and the detection of disease biomarkers for disease diagnosis, treatment, prognosis, and prevention, but also the understanding of interactions between diseases and LMPairs at disease level.<jats:italic>Results<\/jats:italic>. It is well known that genes with similar functions are often associated with similar diseases. In this article, a novel model named PADLMP for predicting associations between diseases and LMPairs is proposed. In this model, a Disease-LncRNA-miRNA (DLM) tripartite network was designed firstly by integrating the lncRNA-disease association network and miRNA-disease association network; then we constructed the disease-LMPairs bipartite association network based on the DLM network and lncRNA-miRNA association network; finally, we predicted potential associations between diseases and LMPairs based on the newly constructed disease-LMPair network. Simulation results show that PADLMP can achieve AUCs of 0.9318, 0.9090 \u00b1 0.0264, and 0.8950 \u00b1 0.0027 in the LOOCV, 2-fold, and 5-fold cross validation framework, respectively, which demonstrate the reliable prediction performance of PADLMP.<\/jats:p>","DOI":"10.1155\/2018\/6789089","type":"journal-article","created":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T23:31:37Z","timestamp":1525649497000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["A Novel Model for Predicting Associations between Diseases and LncRNA-miRNA Pairs Based on a Newly Constructed Bipartite Network"],"prefix":"10.1155","volume":"2018","author":[{"given":"Shunxian","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Software and Communication Engineering, Xiangnan University, Chenzhou 423000, China"},{"name":"College of Information Engineering, Xiangtan University, Xiangtan 411105, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanwei","family":"Xuan","sequence":"additional","affiliation":[{"name":"College of Information Engineering, Xiangtan University, Xiangtan 411105, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-5922","authenticated-orcid":true,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Information Engineering, Xiangtan University, Xiangtan 411105, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyao","family":"Ping","sequence":"additional","affiliation":[{"name":"College of Information Engineering, Xiangtan University, Xiangtan 411105, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingrui","family":"Pei","sequence":"additional","affiliation":[{"name":"College of Information Engineering, Xiangtan University, Xiangtan 411105, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"52","volume":"38","year":"2006","journal-title":"Nature Genetics"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.018"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.006"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2174\/157489361001150309144955"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1101\/gad.234419.113"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.12.051"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.596866"},{"issue":"8","key":"10","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.18632\/oncotarget.1902","volume":"5","year":"2014","journal-title":"Oncotarget"},{"issue":"7","key":"11","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.4103\/0019-509X.154055","volume":"51","year":"2014","journal-title":"Indian Journal of Cancer"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-171"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300849"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12902"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-14-2931"},{"journal-title":"Cancer Biomarkers","first-page":"1","year":"2016","key":"16"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1605-0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb25360g"},{"issue":"2","key":"19","doi-asserted-by":"crossref","first-page":"e32201","DOI":"10.1371\/journal.pone.0032201","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"year":"2005","key":"20"},{"issue":"9","key":"21","doi-asserted-by":"crossref","first-page":"e73191","DOI":"10.1371\/journal.pone.0073191","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks657"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1099"},{"issue":"8","key":"24","doi-asserted-by":"crossref","first-page":"e765","DOI":"10.1038\/cddis.2013.292","volume":"4","year":"2013","journal-title":"Cell Death and Disease"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1094"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn714"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1023"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt014"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1181"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr972"},{"key":"29","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","volume":"42","year":"2014","journal-title":"Nucleic Acids Research"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq241"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11141"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8296"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289026"},{"issue":"1","key":"53","doi-asserted-by":"crossref","first-page":"e87797","DOI":"10.1371\/journal.pone.0087797","volume":"9","year":"2014","journal-title":"PLoS ONE"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/srep16840"},{"issue":"5","key":"36","first-page":"733","volume":"33","year":"2016","journal-title":"Bioinformatics"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/srep21106"},{"issue":"40","key":"39","doi-asserted-by":"crossref","first-page":"65257","DOI":"10.18632\/oncotarget.11251","volume":"7","year":"2016","journal-title":"Oncotarget"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt426"},{"key":"41","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1038\/srep05501","volume":"4","year":"2014","journal-title":"Scientific Reports"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2005.10.010"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31828f9a57"},{"issue":"8","key":"43","doi-asserted-by":"crossref","first-page":"e43821","DOI":"10.1371\/journal.pone.0043821","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-117"},{"issue":"11","key":"45","first-page":"1085","volume":"50","year":"2009","journal-title":"Singapore Medical Journal"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702806200"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elt019"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2014.0135"},{"issue":"1, article 84","key":"49","volume":"33","year":"2014","journal-title":"Journal of Experimental and Clinical Cancer Research"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.12.002"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61729-4"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1871::AID-CNCR28>3.0.CO;2-1"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6789089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6789089.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2018\/6789089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:11:38Z","timestamp":1693660298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2018\/6789089\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":54,"alternative-id":["6789089","6789089"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6789089","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"type":"print","value":"1748-670X"},{"type":"electronic","value":"1748-6718"}],"subject":[],"published":{"date-parts":[[2018]]}}}