{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:58:27Z","timestamp":1740149907926,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Association between <jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic> and colonic pathology is underinvestigated. The aim of this work was to examine the prevalence and nature of colonic changes in children diagnosed with <jats:italic>H. pylori<\/jats:italic> gastritis. <jats:italic>Methods<\/jats:italic>. A comprehensive retrospective review of the medical records for all Manitoban children (\u226417 years) diagnosed with <jats:italic>H. pylori<\/jats:italic> gastritis from January 1996 to May 2015 was conducted. Children with <jats:italic>H. pylori<\/jats:italic> gastritis who had colonoscopy were identified. Patients\u2019 demographics, indications for colonoscopy, laboratory and endoscopic findings, and colonic histopathological abnormalities were documented. <jats:italic>Results<\/jats:italic>. A total of 231 children were found to have <jats:italic>H. pylori<\/jats:italic> gastritis. The mean age at diagnosis was 12.3\u2009\u00b1\u20094.1 years; 108 (46.6%) were girls. Of the 231 patients, 37 (16%) patients were found to have colonoscopy performed. Indications for colonoscopy included bleeding per rectum, significant weight loss, and hypoalbuminemia. Twenty-two (59%) of 37 children who had colonoscopy had significant endoscopic and histopathological findings on colonoscopy including polyposis and colitis. Boys with colonic changes were diagnosed at an earlier age compared to those without (11.5\u2009\u00b1\u20097.0 versus 15.0\u2009\u00b1\u20092.0, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.049<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Our study may suggest a possible association between <jats:italic>H. pylori<\/jats:italic> and a subset of colonic changes in children.<\/jats:p>","DOI":"10.1155\/2018\/6840390","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T19:32:10Z","timestamp":1522697530000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Colonic Abnormalities in Manitoban Children with <i>Helicobacter pylori<\/i> Gastritis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Upama","family":"Banik","sequence":"first","affiliation":[{"name":"Section of Pediatric Gastroenterology, Departments of Pediatrics and Pathology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camelia","family":"Stefanovici","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Departments of Pediatrics and Pathology, College of 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