{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:23:18Z","timestamp":1767626598459,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472036","81501909"],"award-info":[{"award-number":["81472036","81501909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Science Project of National Natural Science Foundation of China","award":["81472036","81501909"],"award-info":[{"award-number":["81472036","81501909"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,6,4]]},"abstract":"<jats:p><jats:italic>Study Design<\/jats:italic>. A retrospective cross-sectional study of type II Modic changes (MCs).<jats:italic> Objective<\/jats:italic>. To evaluate the CT values of type II MCs and determine their relationship with disc degeneration.<jats:italic> Methods<\/jats:italic>. 124 type II MCs from 66 patients\u2019 MRI and CT were included and analyzed. Disc degeneration adjacent to MCs was evaluated based on Pfirrmann classification. CT values of bone marrow area and endplate from MC regions, adjacent non-MC regions, and L1 vertebra were measured. CT value changes (\u0394CT value) were defined as MCs\u2019 CT value minus non-MCs\u2019. According to the types of variables, paired t-test, signed-rank test, two-way ANOVA, and Friedman test were used.<jats:italic> Results<\/jats:italic>. The CT value of MCs was significantly higher than that of non-MCs at both bone marrow area and endplate (P&lt;0.0001, resp.). Good consistency was found between non-MCs and L1 vertebra in the CT value of bone marrow area and endplate (P=0.2129, P=0.2272, resp.), suggesting the control group was valid. Adjacent to type II MCs, there were 8 (6.4%) discs with grade III degeneration, 58 (46.8%) with grade IV, and 58 (46.8%) with grade V. The \u0394CT value of grade V disc degeneration was larger than that of grade IV at the endplate (P=0.0150).<jats:italic> Conclusions<\/jats:italic>. Osteosclerosis may exist in type II MCs. The more severe the degeneration of the adjacent disc, the greater the degree of osteosclerosis.<\/jats:p>","DOI":"10.1155\/2018\/6853720","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T19:31:49Z","timestamp":1528140709000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["The Pathology of Type II Modic Changes: Fat Deposition or Osteosclerosis? A Study Using CT Scan"],"prefix":"10.1155","volume":"2018","author":[{"given":"Chi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-8096","authenticated-orcid":true,"given":"Jianyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feizhou","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"},{"name":"The Fifth People\u2019s Hospital of Shanghai, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000157424.72598.ec"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000232802.95773.89"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a0925"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.3.531"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.1.3336678"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.1.3289089"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-008-0590-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-007-0336-8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-006-0301-y"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001526"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.098"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00011"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2012.03.026"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150650"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00124"},{"issue":"5","key":"16","first-page":"757","volume":"76","year":"1994","journal-title":"The Journal of Bone & Joint Surgery (British Volume)"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1407-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050469"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.03.019"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.06.056"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4584-z"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/6853720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/6853720.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/6853720.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T19:31:55Z","timestamp":1528140715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/6853720\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":21,"alternative-id":["6853720","6853720"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6853720","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2018,6,4]]}}}