{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:07:47Z","timestamp":1787508467300,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:00:00Z","timestamp":1524355200000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005601","name":"University of Ghana","doi-asserted-by":"publisher","award":["URF\/7\/SF-011\/2013-2"],"award-info":[{"award-number":["URF\/7\/SF-011\/2013-2"]}],"id":[{"id":"10.13039\/501100005601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:italic>Trichilia monadelpha<\/jats:italic>\n                    is a common medicinal plant used traditionally in treating central nervous system conditions such as epilepsy, depression, pain, and psychosis. In this study, the antidepressant\u2010like effect of crude extracts of the stem bark of\n                    <jats:italic>T. monadelpha<\/jats:italic>\n                    was investigated using two classical murine models, forced swimming test (FST) and tail suspension test (TST). The extracts, petroleum ether, ethyl acetate, and hydroethanolic extracts (30\u2013300\u2009mg\/kg,\n                    <jats:italic>p.o.<\/jats:italic>\n                    ), standard drug (imipramine; fluoxetine, 3\u201330\u2009mg\/kg,\n                    <jats:italic>p.o.<\/jats:italic>\n                    ), and saline (vehicle) were given to mice one hour prior to the acute study. In a separate experiment the components (flavonoids, saponins, alkaloids, tannins, and terpenoids; 30\u2013300\u2009mg\/kg,\n                    <jats:italic>p.o.<\/jats:italic>\n                    ) from the most efficacious extract fraction were screened to ascertain which components possessed the antidepressant effect. All the extracts and components significantly induced a decline in immobility in the FST and TST, indicative of an antidepressant\u2010like activity. The extracts and some components showed increase in swimming and climbing in the FST as well as a significant enhancement in swinging and\/or curling scores in the TST, suggesting a possible involvement of monoaminergic and\/or opioidergic activity. This study reveals the antidepressant\u2010like potential of the stem bark extracts and components of\n                    <jats:italic>T. monadelpha<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2018\/6863973","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T19:32:03Z","timestamp":1524425523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antidepressant Potentials of Components from\n                    <i>Trichilia monadelpha<\/i>\n                    (Thonn.) 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