{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:45:40Z","timestamp":1788039940577,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018,9,3]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. In this study, we investigated the status of thyroid function and its association with metabolic risk factors in Korean adolescents. <jats:italic>Methods<\/jats:italic>. Among 2679 subjects aged 10\u201319 years who participated in the Korea National Health and Nutrition Examination Survey VI (2013\u20132015), 1067 adolescents (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>M<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>559<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>F<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>508<\/mml:mn><\/mml:math>) with available data on free T4 (FT4) and thyroid-stimulating hormone (TSH) were included. Study participants were classified into normal weight [body mass index (BMI) below 85th percentile, 80.7%], overweight (85th\u2009\u2264\u2009BMI&lt;\u200995th percentile, 8.7%), and obesity (BMI\u2009\u2265\u200995th percentile, 10.6%). <jats:italic>Results<\/jats:italic>. With increasing levels of BMI category, the means of TSH increased (2.73\u2009\u00b1\u20090.06, 2.77\u2009\u00b1\u20090.02, and 3.24\u2009\u00b1\u20090.22\u2009mIU\/L, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.031<\/mml:mn><\/mml:math>) and FT4 decreased (1.30\u2009\u00b1\u20090.01, 1.26\u2009\u00b1\u20090.02, and 1.25\u2009\u00b1\u20090.02\u2009ng\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Positive linear associations were observed between TSH and BMI <jats:italic>z<\/jats:italic>-score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.031<\/mml:mn><\/mml:math>), waist circumference (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.013<\/mml:mn><\/mml:math>), waist-height ratio (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>), systolic blood pressure (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), total cholesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>), and triglyceride (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>) after adjusting for age and sex. With per-unit increase in TSH, the odds ratios of having abdominal obesity (OR\u2009=\u20091.18, 95% CI, 1.01\u20131.38) and triglyceride\u2009\u2265\u2009150\u2009mg\/dL (OR\u2009=\u20091.18, 95% CI, 1.04\u20131.34) were significantly increased after adjusting for age, sex, and BMI. <jats:italic>Conclusions<\/jats:italic>. In adolescents with obesity, TSH was higher and FT4 was lower than in adolescents with normal weight. Hyperthyrotropinemia was associated with abnormal metabolic risk factors including abdominal obesity and elevated triglyceride.<\/jats:p>","DOI":"10.1155\/2018\/6874395","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T19:33:10Z","timestamp":1536003190000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Thyroid Function in Korean Adolescents with Obesity: Results from the Korea National Health and Nutrition Examination Survey VI (2013\u20132015)"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-0565","authenticated-orcid":true,"given":"Won Kyoung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, St. Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Gyeonggi-do 16247, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Kyoung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu Seoul 08308, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-7443","authenticated-orcid":true,"given":"Jae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 13620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-6469","authenticated-orcid":true,"given":"Young-Jun","family":"Rhie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan, Gyeonggi-do 15355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sochung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 05030, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Korea University Anam Hospital, 73 Inchon-ro, Seongbuk-gu Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-0232","authenticated-orcid":true,"given":"Byung-Kyu","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of 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