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Hepatoprotective compounds, such as antioxidants, can prevent fibrosis. Macroalgae (seaweed) contain high amounts of antioxidant compounds and are plentiful; indeed, species such as<jats:italic> Sargassum fluitans <\/jats:italic>Borgesen (Phaeophyceae) carpet many beaches in the Caribbean Basin. An<jats:italic> in vivo<\/jats:italic> assay was done evaluating the possible hepatoprotective effect of a<jats:italic> Sargassum fluitans <\/jats:italic>ethanol extract. Two murine liver damage models were employed: acetaminophen (APAP) in Balb\/c mice to induce acute damage; carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) in Wistar rats to induce chronic damage. Serum liver enzyme levels and relative liver weight were measured, and histopathological and immunohistochemical analyses of liver tissue sections were done. Both APAP and CCl<jats:sub>4<\/jats:sub> significantly raised serum enzyme marker enzymes. Administration of 50 mg\/kg<jats:italic> S. Fluitans <\/jats:italic>ethanol extract reduced this APAP- and CCl<jats:sub>4<\/jats:sub>-induced elevation to normal levels. This effect was corroborated by the extract\u2019s inhibition of inflammation and fibrosis in liver tissue observed in the histopathological analysis. The analyzed<jats:italic> S. fluitans <\/jats:italic>ethanol extract exhibited an<jats:italic> in vivo<\/jats:italic> hepatoprotective effect in acute and chronic liver injury models.<\/jats:p>","DOI":"10.1155\/2018\/6921845","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T18:42:30Z","timestamp":1545331350000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["A<i> Sargassum fluitans<\/i> Borgesen Ethanol Extract Exhibits a Hepatoprotective Effect<i> In Vivo<\/i> in Acute and Chronic Liver Damage Models"],"prefix":"10.1155","volume":"2018","author":[{"given":"Carlos","family":"Quintal-Novelo","sequence":"first","affiliation":[{"name":"Unidad M\u00e9dica de Alta Especialidad, Centro M\u00e9dico \u201cIgnacio Garc\u00eda T\u00e9llez\u201d, Instituto Mexicano del Seguro Social, Calle 41 No. 439, Col. 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