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We previously demonstrated interleukin\u20104 (IL\u20104) improves insulin sensitivity and glucose tolerance while reducing lipid deposits. The present study examined the <jats:italic>in vitro<\/jats:italic> effects of IL\u20104 on insulin signaling molecules, glucose uptake, and lipid metabolism in hepatocytes, as well as <jats:italic>in vivo<\/jats:italic> effects on hepatic adiposity, for elucidating the roles of IL\u20104 in hepatic energy metabolism. Potential interaction between IL\u20104 and insulin in regulating hepatic metabolism was also investigated. Our results showed that IL\u20104 enhanced Akt and GSK\u20103<jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic> phosphorylations, which in turn promoted glycogen synthesis. IL\u20104 not only potentiated basal glucose uptake by upregulating glucose transporter 2 expression but also promoted insulin\u2010induced glucose uptake. Additionally, IL\u20104 increased triglyceride contents through facilitating free fatty acid uptake and expression\/activity of lipogenic enzymes. The major effects of IL\u20104 on the liver were to promote energy storage by boosting insulin\u2010stimulated glucose uptake and lipid synthesis. This study provides evidence to implicate the novel roles of IL\u20104 in mediating hepatic glucose and lipid metabolism, interactions between immune responses and metabolic homeostasis, and the involvement of IL\u20104 in metabolic abnormalities.<\/jats:p>","DOI":"10.1155\/2018\/6923187","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T23:31:39Z","timestamp":1542843099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Interleukin\u20104 Boosts Insulin\u2010Induced Energy Deposits by Enhancing Glucose Uptake and Lipogenesis in 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