{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:23:42Z","timestamp":1769646222234,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003486","name":"Hellenic Rheumatology Society","doi-asserted-by":"publisher","award":["731944"],"award-info":[{"award-number":["731944"]}],"id":[{"id":"10.13039\/501100003486","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004343","name":"Stavros Niarchos Foundation","doi-asserted-by":"publisher","award":["731944"],"award-info":[{"award-number":["731944"]}],"id":[{"id":"10.13039\/501100004343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["731944"],"award-info":[{"award-number":["731944"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018,12,19]]},"abstract":"<jats:p>Tumor necrosis factor, alpha-induced protein 3 (<jats:italic>TNFAIP3<\/jats:italic>) gene encodes the A20 protein, an important negative feedback regulator of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-<jats:italic>\u03ba<\/jats:italic>B) pathway. A coding <jats:italic>TNFAIP3<\/jats:italic> variant, namely rs2230926, has been previously linked to B cell non-Hodgkin\u2019s lymphoma (NHL) development in patients with Sjogren\u2019s syndrome (SS) of French and UK origin. Herein, we aimed to determine the prevalence of rs2230926 in a Greek primary SS cohort and explore possible associations with disease characteristics. The rs2230926 gene variant was genotyped in 327 primary Greek SS patients (ninety-one complicated by NHL (SS-lymphoma)) and 448 Greek healthy controls (HC) of similar age and sex distribution. Clinical and laboratory characteristics were also recorded and gene expression of relevant genes of the NF-<jats:italic>\u03ba<\/jats:italic>B pathway was quantitated by real-time PCR in available whole peripheral blood (PB) from 165 primary SS patients. Increased prevalence of the rs2230926 mutant variant was detected in both SS-lymphoma and SS-nonlymphoma subgroups compared to HC (8.8% vs. 7.6% vs. 3.6%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><\/mml:math> values: 0.04 and 0.03, respectively) in association with higher IgM, LDH serum levels, and PB <jats:italic>Bcl-XL<\/jats:italic> transcripts but lower leucocyte and neutrophil counts. Of interest, approximately one-fifth of SS-lymphoma cases with age at disease onset\u2009\u2264\u200940 years carried the rs2230926 variant (18.2% vs. 3.6%, OR 95% (CI): 6.0 (1.8\u201319.8), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><\/mml:math> value: 0.01). We postulate that deregulation of the NF-<jats:italic>\u03ba<\/jats:italic>B pathway as a result of the <jats:italic>TNFAIP3<\/jats:italic> rs2230926 aberration increases SS and SS lymphoma susceptibility particularly in patients with early disease onset.<\/jats:p>","DOI":"10.1155\/2018\/6923213","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T18:31:05Z","timestamp":1545244265000},"page":"1-8","source":"Crossref","is-referenced-by-count":27,"title":["TNFAIP3 F127C Coding Variation in Greek Primary Sjogren\u2019s Syndrome Patients"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-146X","authenticated-orcid":true,"given":"Adrianos","family":"Nezos","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliona","family":"Gkioka","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-9916","authenticated-orcid":true,"given":"Michael","family":"Koutsilieris","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Voulgarelis","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios G.","family":"Tzioufas","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-7406","authenticated-orcid":true,"given":"Clio P.","family":"Mavragani","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, School of Medicine, Athens, 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