{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:14:36Z","timestamp":1788448476861,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia. It has a heterogeneous etiology and clinical course. This study aimed to examine the factors associated with the progression of MCI in different types of dementia disorders.<jats:italic>Method<\/jats:italic>. A retrospective, longitudinal, observational study of outpatients with MCI was conducted at a medical center in northern Taiwan. Patient medical records were reviewed, and risk factors were analyzed by multivariate analysis.<jats:italic>Results<\/jats:italic>. Among 279 patients with MCI, 163 (58.4%), 68 (24.4%), and 48 (17.2%) were diagnosed with Alzheimer\u2019s disease, vascular cognitive impairment, and Lewy body diseases, respectively. During the observation period, 37.2% of patients progressed to dementia. Older age and a higher Clinical Dementia Rating Scale-Sum of Boxes were associated with the risk of progression. Hyperlipidemia was associated with a decreased risk. Converters were more likely to receive an antidementia prescription.<jats:italic>Conclusion<\/jats:italic>. Our study suggests the importance of comprehensive clinical profiling, risk factor assessment, and detailed drug history evaluations in improving our understanding and management of dementia subtypes.<\/jats:p>","DOI":"10.1155\/2018\/6929732","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T19:33:17Z","timestamp":1528227197000},"page":"1-8","source":"Crossref","is-referenced-by-count":33,"title":["Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-3088","authenticated-orcid":true,"given":"Pei-Hao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, MacKay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"},{"name":"Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, MacKay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"},{"name":"Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, MacKay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuo-Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, MacKay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"},{"name":"Graduate Institute of Chemistry, Tamkang University, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-6853","authenticated-orcid":true,"given":"Chih-Ho","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan"},{"name":"Chia Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.016"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04081.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijge.2017.07.004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000138"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000458"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex169"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175475"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000178"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0727-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160381"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.8.1091"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010783.pub2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1159\/000089218"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000313"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000034"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"25","year":"2013"},{"issue":"1","key":"26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.32607\/20758251-2016-8-1-58-73","volume":"8","year":"2016","journal-title":"Acta Naturae"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2017.4"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160826"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.11.002"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003160.pub3"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2116"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2012.05.004"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002778"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.2361"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijge.2017.03.010"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i90"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000809"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513504611"}],"container-title":["Behavioural Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bn\/2018\/6929732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bn\/2018\/6929732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bn\/2018\/6929732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T23:37:37Z","timestamp":1571441857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bn\/2018\/6929732\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":38,"alternative-id":["6929732","6929732"],"URL":"https:\/\/doi.org\/10.1155\/2018\/6929732","relation":{},"ISSN":["0953-4180","1875-8584"],"issn-type":[{"value":"0953-4180","type":"print"},{"value":"1875-8584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]}}}