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To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and evaluated by 16S ribosomal RNA gene sequence and quantitative real-time PCR. A mouse model of postinfectious IBS (PI-IBS) was established to determine whether the altered gut microbiota was associated with increased visceral hypersensitivity. The results indicated that there were significant differences in the bacterial community profiles between IBS-D patients and healthy controls.\n                    <jats:italic>Prevotella<\/jats:italic>\n                    was more abundant in fecal samples from IBS-D patients compared with healthy controls (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). Meanwhile, there were significant reductions in the quantity of\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    ,\n                    <jats:italic>Bifidobacteria<\/jats:italic>\n                    , and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    in IBS-D patients compared with healthy controls (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). Animal models similarly showed an increased abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    in fecal samples compared with control mice (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ). Finally, after the PI-IBS mice were cohoused with control mice, both the relative abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    and visceral hypersensitivity of PI-IBS mice were decreased. In conclusion, the altered intestinal microbiota is associated with increased visceral hypersensitivity and enterotype enriched with\n                    <jats:italic>Prevotella<\/jats:italic>\n                    may be positively associated with high risk of IBS-D.\n                  <\/jats:p>","DOI":"10.1155\/2018\/6961783","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T19:32:40Z","timestamp":1528227160000},"page":"1-9","source":"Crossref","is-referenced-by-count":96,"title":["Altered Intestinal Microbiota with Increased Abundance of\n                    <i>Prevotella<\/i>\n                    Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome"],"prefix":"10.1155","volume":"2018","author":[{"given":"Tingting","family":"Su","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-7949","authenticated-orcid":true,"given":"Jianmin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung","family":"Owyang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University of 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