{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:09:00Z","timestamp":1762474140527,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Sirenomelia is a rare congenital malformation characterized by varying degrees of fusion of the lower extremities. It is commonly associated with severe urogenital and gastrointestinal malformations; however, the association of sirenomelia with anencephaly and rachischisis totalis is extremely rare. To our knowledge, the prenatal sonographic images of this association have not been previously published. Here, we present prenatal sonographic images of this association, detected during the 17th week of gestation through combined two\u2010dimensional, four\u2010dimensional, and color Doppler ultrasound. Two\u2010dimensional ultrasound images showed anencephaly, spina bifida, and possible fusion of the lower limbs. Three\u2010dimensional HDlive rendering images confirmed the final diagnosis of sirenomelia with anencephaly and rachischisis totalis. The patient opted to undergo medical termination of pregnancy and delivered a fetus with fused lower limbs, anencephaly, and rachischisis totalis confirming the\n                    <jats:italic>in utero<\/jats:italic>\n                    imaging findings. Awareness of these rare associations will help avoid misdiagnoses and facilitate prenatal counselling. This case highlights the importance of a thorough ultrasound examination.\n                  <\/jats:p>","DOI":"10.1155\/2018\/7058253","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:30:45Z","timestamp":1543429845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Sonographic Image of Sirenomelia with Anencephaly and Craniorachischisis Totalis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Takako","family":"Sugiura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Nakanami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-2678","authenticated-orcid":false,"given":"Kiyomi","family":"Tsukimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_6_1_2","first-page":"7","article-title":"Sirenomelia. A morphological study of 33 cases and review of the literature.","volume":"10","author":"Stocker J. T.","year":"1987","journal-title":"Perspectives in Pediatric Pathology"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430416"},{"key":"e_1_2_6_3_2","first-page":"1041","article-title":"Sirenomelia Sequence Associated with Craniorachischisis Totalis, Limb Reduction and Primitive Heart","volume":"38","author":"Halder A.","year":"2001","journal-title":"Indian Pediatrics"},{"key":"e_1_2_6_4_2","article-title":"Prenatal diagnosis of sirenomelia with anencephaly and craniorachischisis totalis: A case report study","volume":"96","author":"Theofanakis C.","year":"2017","journal-title":"Medicine (United States)"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007732"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13030196.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1989.8.2.83"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.8.915"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.624"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1479"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236359"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10112"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2505-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2016.15201"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-012-0420-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-013-0466-z"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30324"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2847-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2011.00326.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01822"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.78.3.451"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32081"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23125"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.09.007"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e328354e51b"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33460"},{"key":"e_1_2_6_27_2","first-page":"163","article-title":"Sirenomelia with oesophageal atresia: A rare association","volume":"8","author":"Aditya Sathe P.","year":"2014","journal-title":"Journal of Clinical and Diagnostic Research"}],"container-title":["Case Reports in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criog\/2018\/7058253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criog\/2018\/7058253.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/7058253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:04:09Z","timestamp":1762473849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/7058253"}},"subtitle":[],"editor":[{"given":"Dotun","family":"Ogunyemi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/7058253"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7058253","archive":["Portico"],"relation":{},"ISSN":["2090-6684","2090-6692"],"issn-type":[{"type":"print","value":"2090-6684"},{"type":"electronic","value":"2090-6692"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7058253"}}