{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:16:08Z","timestamp":1789229768942,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008348","name":"Dumlupinar \u00dcniversitesi","doi-asserted-by":"publisher","award":["2016-61"],"award-info":[{"award-number":["2016-61"]}],"id":[{"id":"10.13039\/501100008348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR).<jats:italic>Methods.<\/jats:italic>Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study. In addition to this patient group, patients with diabetes but without DFU were determined as the control group.<jats:italic>Results.<\/jats:italic>Thirty-eight patients with IDFU, 38 patients with NIDFU, and 43 patients as the control group were included in the study. Fifty-six point three percent of the patients who participated in the study were males, and the mean age was 61.07\u2009\u00b1\u200911.04 years. WBC, ESR, CRP, IL-6, and fibrinogen levels of the cases with IDFU were determined to be significantly higher compared to the cases in NIDFU (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The area under the ROC curve (AUROC) value was highest for CRP (0.998;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and the best cut-off value for CRP was 28\u2009m\/L. The best cut-off values for fibrinogen, IL-6, ESR, and WBC were 480\u2009mg\/dL, 105.8\u2009pg\/mL, 31\u2009mm\/h, and 11.6 (103\u2009<jats:italic>\u03bc<\/jats:italic>\/L), respectively.<jats:italic>Conclusion.<\/jats:italic>Serum PCT levels were not found to be effective in the discrimination of IDFU and NIDFU. Serum IL-6 and fibrinogen levels seem to be two promising inflammatory markers in the discrimination of IDFU.<\/jats:p>","DOI":"10.1155\/2018\/7104352","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T23:35:17Z","timestamp":1519256117000},"page":"1-7","source":"Crossref","is-referenced-by-count":44,"title":["The Role of Serum Procalcitonin, Interleukin-6, and Fibrinogen Levels in Differential Diagnosis of Diabetic Foot Ulcer Infection"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-5895","authenticated-orcid":true,"given":"P\u0131nar","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Dumlup\u0131nar University Faculty of Medicine, 43020 Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Havva","family":"Ko\u00e7ak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Dumlup\u0131nar University Faculty of Medicine, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevser","family":"Onba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Dumlup\u0131nar University Faculty of Medicine, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polat","family":"Bi\u00e7ici","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, K\u00fctahya Dumlup\u0131nar Training and Research Hospital, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, K\u00fctahya Dumlup\u0131nar Training and Research Hospital, Kutahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemile","family":"Uyar","sequence":"additional","affiliation":[{"name":"Department 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