{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:45:42Z","timestamp":1788295542098,"version":"build-2803163510"},"reference-count":112,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Muscle wasting is one of the main features of cancer cachexia, a multifactorial syndrome frequently occurring in oncologic patients. The onset of cachexia is associated with reduced tolerance and response to antineoplastic treatments, eventually leading to clinical conditions that are not compatible with survival. Among the mechanisms underlying cachexia, protein and energy dysmetabolism play a major role. In this regard, several potential treatments have been proposed, mainly on the basis of promising results obtained in preclinical models. However, at present, no treatment yet reached validation to be used in the clinical practice, although several drugs are currently tested in clinical trials for their ability to improve muscle metabolism in cancer patients. Along this line, the results obtained in both experimental and clinical studies clearly show that cachexia can be effectively approached by a multidirectional strategy targeting nutrition, inflammation, catabolism, and inactivity at the same time. In the present study, approaches aimed to modulate muscle metabolism in cachexia will be reviewed.<\/jats:p>","DOI":"10.1155\/2018\/7153610","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T23:31:25Z","timestamp":1517268685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Modulating Metabolism to Improve Cancer\u2010Induced Muscle Wasting"],"prefix":"10.1155","volume":"2018","author":[{"given":"Fabio","family":"Penna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Ballar\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Beltr\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"De Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7230","authenticated-orcid":false,"given":"Paola","family":"Costelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12206"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0255"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.07.023"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1345"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.10.005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170032"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000048"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055225.96357.71"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.09.012"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.063859"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-09-0704"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1100356"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.12.023"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26991"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30340"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610123"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1036"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00213"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21893"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/805172"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2010.503773"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68523"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.058388"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.031"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2772"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.031"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12050"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1412-6"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01001-12"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.5.E996"},{"key":"e_1_2_6_34_2","first-page":"5568","article-title":"Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats","volume":"54","author":"Temparis S.","year":"1994","journal-title":"Cancer Research"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5396"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0425"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2081-3"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116897"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6445.584"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3383"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12029"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000236"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00104.2006"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25146"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0369"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060228"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.05.003"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.05.008"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv271"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000390"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S110131"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3144-z"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00929498"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3130077"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1479"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.08.007"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)03719-Y"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)49943-7"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070651"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2811-2"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000172581.79266.19"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758834017698643"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.11.012"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00823-1"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/014860710402800265"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0403-7"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00629-3"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317695960"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e32834bde0e"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600074"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.11.009"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6439"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0071-9"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1998"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3292087"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.019"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-2-14"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0028-4"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.10.003"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0157-8"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.007"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00952.2011"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00380.2016"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-242123"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.050"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033426"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-238071"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.051"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.004"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.10.010"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810666140918121022"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2424-9"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0482"},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.10.002"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4171"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_2_6_98_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328328d0a4"},{"key":"e_1_2_6_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.489716"},{"key":"e_1_2_6_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3985"},{"key":"e_1_2_6_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601633"},{"key":"e_1_2_6_102_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051395"},{"key":"e_1_2_6_103_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.487736"},{"key":"e_1_2_6_104_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000042"},{"key":"e_1_2_6_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12220"},{"key":"e_1_2_6_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.01.006"},{"key":"e_1_2_6_107_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12484"},{"key":"e_1_2_6_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.01.003"},{"key":"e_1_2_6_109_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12097"},{"key":"e_1_2_6_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4093"},{"key":"e_1_2_6_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.209"},{"key":"e_1_2_6_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.015"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/7153610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/7153610.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/7153610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:29:03Z","timestamp":1723030143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/7153610"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Filomeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/7153610"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7153610","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7153610"}}