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This method induces elevated T cell function with mild graft-versus-host disease (GVHD) in comparison to conventional HSCT alone and HSCT\u2009+\u2009donor lymphocyte infusion (DLI). This new method is effective against several intractable diseases, including malignant tumors, for which conventional treatments are ineffective. Regulatory T (T<jats:sub>reg<\/jats:sub>) cells play an important role in the enhanced graft-versus-tumor (GVT) effect and reduction of GVHD, thus leading to longer survival. Replacement and reduction of elevated T<jats:sub>reg<\/jats:sub>cells by donor-derived allo-T<jats:sub>reg<\/jats:sub>cells from the transplanted thymus may play one of crucial roles in the effect. This review discusses the role of T<jats:sub>reg<\/jats:sub>cells in a tumor-bearing mouse model treated with allo-HSCT\u2009+\u2009TT.<\/jats:p>","DOI":"10.1155\/2018\/7271097","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:43:47Z","timestamp":1530578627000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Role of Regulatory T Cells in Tumor-Bearing Mice Treated with Allo-Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8472-7826","authenticated-orcid":true,"given":"Naoki","family":"Hosaka","sequence":"first","affiliation":[{"name":"Department of Pathology, Fuchu Hospital, 1-10-7, Hiko-cho, Izumi, Osaka 594-0076, Japan"},{"name":"Department of Public Health, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, 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