{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:02:08Z","timestamp":1787731328474,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tunisian Ministry of Higher Education and Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>\n                    Over the last few decades,\n                    <jats:italic>Rumex<\/jats:italic>\n                    species have been recognized as a promising source of new compounds with numerous pharmacological activities. Therefore, the antioxidant activity of\n                    <jats:italic>Rumex tingitanus (R. tingitanus)<\/jats:italic>\n                    leaves extracts was evaluated\n                    <jats:italic>in vitro<\/jats:italic>\n                    and then confirmed\n                    <jats:italic>in vivo<\/jats:italic>\n                    as well as the antidepressant-like and toxicological effects of the extracts. The ethyl acetate fraction (Rt EtOAcF) followed by hydroalcoholic extract (Rt EtOH-H\n                    <jats:sub>2<\/jats:sub>\n                    O) showed a remarkable\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidant activity. The hydroalcoholic extract (Rt EtOH-H\n                    <jats:sub>2<\/jats:sub>\n                    O) showed significant hepatoprotective activity against carbon tetrachloride- (CCl\n                    <jats:sub>4<\/jats:sub>\n                    -) induced liver toxicity which is seen from inhibition of the malondialdehyde (MDA) accumulation and enhancement of the liver antioxidant enzymes activities. The Rt EtOH-H\n                    <jats:sub>2<\/jats:sub>\n                    O and Rt EtOAcF extracts were able to reduce the immobility time in mice and then elicited a significant antidepressant-like effect. The ethyl acetate fraction (Rt EtOAcF) was purified and resulted in the identification of a new antioxidant component called 4\u2032-\n                    <jats:italic>p<\/jats:italic>\n                    -acetylcoumaroyl luteolin. The Rt EtOAcF and the 4\u2032-\n                    <jats:italic>p<\/jats:italic>\n                    -acetylcoumaroyl luteolin revealed a strong antioxidant activity using DPPH test with IC\n                    <jats:sub>50<\/jats:sub>\n                    of 11.7 \u00b1 0.2 and 20.74 \u00b1 0.6\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/ml, respectively, and AAI of 3.39 and 1.92 better than that of BHT, used as control.\n                  <\/jats:p>","DOI":"10.1155\/2018\/7295848","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T19:35:55Z","timestamp":1521401755000},"page":"1-10","source":"Crossref","is-referenced-by-count":13,"title":["Antioxidant, Hepatoprotective, and Antidepression Effects of\n                    <i>Rumex tingitanus<\/i>\n                    Extracts and Identification of a Novel Bioactive Compound"],"prefix":"10.1155","volume":"2018","author":[{"given":"Dhekra","family":"Mhalla","sequence":"first","affiliation":[{"name":"Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-6877","authenticated-orcid":true,"given":"Karama","family":"Zouari Bouassida","sequence":"additional","affiliation":[{"name":"Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Chawech","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. Box 1171, 3000 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. Box 1171, 3000 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Makni","sequence":"additional","affiliation":[{"name":"Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lobna","family":"Jlaiel","sequence":"additional","affiliation":[{"name":"Analysis Service of the Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-0122","authenticated-orcid":true,"given":"Slim","family":"Tounsi","sequence":"additional","affiliation":[{"name":"Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoudha","family":"Mezghani Jarraya","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. Box 1171, 3000 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-0293","authenticated-orcid":true,"given":"Mohamed","family":"Trigui","sequence":"additional","affiliation":[{"name":"Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia"},{"name":"Research Unit \u201cCoastal and Urban Environments\u201d, Sfax Preparatory Engineering Institute, University of Sfax, BP 1172, 3018 Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.05.055"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/601503"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803523554"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/65.2.166"},{"key":"6","first-page":"93","volume":"23","year":"1954","journal-title":"Indian Journal of Surgery"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.09.001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17010843"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jher.2013.02.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2016.11.011"},{"key":"11","first-page":"150","volume":"1","year":"2010","journal-title":"International Journal on Pharmaceutical and Biomedical Research"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0160-9327(73)90028-8"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00196-3"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.003"},{"issue":"59","key":"15","first-page":"3638","volume":"10","year":"2012","journal-title":"Journal of visualized experiments : JoVE"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.04.011"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90489-1"},{"key":"19","volume":"2","year":"1974"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"21","volume-title":"Les colorations","year":"1968"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.01.028"},{"issue":"2","key":"23","first-page":"105","volume":"9","year":"1998","journal-title":"Reviews in the Neurosciences"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2009.268.272"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1021\/jf034790i"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1016\/0002-9343(91)90279-7","volume":"91","year":"1991","journal-title":"American Journal of Medicine"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2003.07.024"},{"key":"28","first-page":"891","volume":"3","year":"2014","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.12.045"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.08.004"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/217037"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781107477278"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1021\/jf021159t"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-47"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02370.x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(03)00043-6"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7295848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7295848.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7295848.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T19:35:59Z","timestamp":1521401759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/7295848\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":36,"alternative-id":["7295848","7295848"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7295848","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}