{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:34:13Z","timestamp":1790876053964,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation South Africa"},{"DOI":"10.13039\/501100004695","name":"Inyuvesi Yakwazulu-Natali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,6,13]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Studies suggest that<jats:italic>Momordica balsamina<\/jats:italic>(<jats:italic>intshungu<\/jats:italic>) possesses hypoglycaemic effects. The effects of<jats:italic>Momordica balsamina<\/jats:italic>on diabetic complications such as DN, however, have not been established. Accordingly, this study seeks to investigate the effects of<jats:italic>M. balsamina<\/jats:italic>on kidney function in STZ-induced diabetic rats.<jats:italic>Methods<\/jats:italic>. Methanolic extracts (ME) of<jats:italic>M. balsamina<\/jats:italic>\u2019s leaves were used in this study. Short-term effects of<jats:italic>M. balsamina<\/jats:italic>methanolic extract on kidney function and MAP were studied in STZ-induced diabetic rats treated twice daily with<jats:italic>M. balsamina<\/jats:italic>methanolic extract (250\u2009mg\/kg), insulin (175\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg, s.c.), and metformin (500\u2009mg\/kg) for 5 weeks.<jats:italic>Results<\/jats:italic>.<jats:italic>M. balsamina<\/jats:italic>methanolic extract significantly increased Na<jats:sup>+<\/jats:sup>excretion outputs in STZ-induced diabetic rats by comparison to STZ-diabetic control rats.<jats:italic>M. balsamina<\/jats:italic>methanolic extract significantly increased GFR in STZ-diabetic rats with a concomitant decrease in creatinine concentration and also reduced kidney-to-body ratio, albumin excretion rate (AER), and albumin creatinine ratio (ACR).<jats:italic>M. balsamina<\/jats:italic>methanolic extract significantly reduced MAP in STZ-diabetic animals by comparison with STZ-diabetic control animals. These results suggest that<jats:italic>M. balsamina<\/jats:italic>methanolic extract not only lowers blood glucose but also has beneficial effects on kidney function and blood pressure.<jats:italic>Conclusion<\/jats:italic>. These findings suggest that<jats:italic>M. balsamina<\/jats:italic>may have beneficial effects on some processes that are associated with renal derangement in STZ-induced diabetic rats.<\/jats:p>","DOI":"10.1155\/2018\/7341242","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T23:51:49Z","timestamp":1528933909000},"page":"1-8","source":"Crossref","is-referenced-by-count":27,"title":["The Effects of<i>Momordica balsamina<\/i>Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers"],"prefix":"10.1155","volume":"2018","author":[{"given":"Anelisiwe","family":"Siboto","sequence":"first","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntethelelo","family":"Sibiya","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences, 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