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To assess the therapeutic efficacy and safety of botulinum toxin type A (BTX-A) for treating idiopathic trigeminal neuralgia (ITN) in patients \u226580 years old. <jats:italic>Methods<\/jats:italic>. Selected patients <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>43<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math> with ITN, recruited from the neurology clinic and inpatient department of the Second Affiliated Hospital of Soochow University between August 2008 and February 2014, were grouped by age, one subset <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math> \u226580 years old and another <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>29<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math> &lt;60 years old. Each group scored similarly in degrees of pain registered by the visual analogue scale (VAS). Dosing, efficacy, and safety of BTX-A injections were compared by group. <jats:italic>Results<\/jats:italic>. Mean dosages of BTX-A were 91.3\u2009\u00b1\u200925.6\u2009U and 71.8\u2009\u00b1\u200933.1\u2009U in older and younger patients, respectively <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>t<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1.930<\/mml:mn><mml:mo>,<\/mml:mo><mml:mtext>\u2009<\/mml:mtext><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.061<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math>. The median of the VAS score in older patients at baseline (8.5) declined significantly at 1 month after treatment (4.5) <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math>, as did that of younger patients (8.0 and 5.0, resp.) <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math>. The median of the D values of the VAS scores did not differ significantly by group (older, 2.5; younger, 0; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>Z<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>1.073<\/mml:mn><\/mml:mrow><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.283<\/mml:mn><\/mml:mrow><\/mml:math>). Two patients in each group developed minor transient side effects <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mrow><mml:mfenced open=\"(\" close=\")\" separators=\"|\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.825<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:mrow><\/mml:math>. Adverse reactions in both groups were mild, resolving spontaneously within 3 weeks. <jats:italic>Conclusions<\/jats:italic>. BTX-A is effective and safe in treating patients of advanced age (\u226580 years old) with ITN, at dosages comparable to those used in much younger counterparts (&lt;60 years old).<\/jats:p>","DOI":"10.1155\/2018\/7365148","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T01:20:54Z","timestamp":1522977654000},"page":"1-5","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-1700","authenticated-orcid":true,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China"},{"name":"Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psychiatric-Diseases, 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