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In consequence, much attention is paid to the use of antihypertensive drugs that can be used safely during pregnancy. Several side effects of methyldopa, which is currently the most commonly used antihypertensive drug in pregnant women, mean that the search for an effective and safe alternative still continues. Flavonoid compounds present in medicinal plants, vegetables, and fruits may be a promising source of new drugs. In this aspect, quercetin, a well\u2010known flavonoid due to its antihypertensive action, may be considered a prototype for safe antihypertensive drugs. This review focuses on the selective activity of quercetin. Based on recent studies, a few problems were discussed, including (1) pathology of pregnancy\u2010induced hypertension; (2) search for new pharmacological treatments of pregnancy\u2010induced hypertension; (3) issues with the use of herbal extracts during pregnancy; (4) flavonoids as natural active chemical compounds; (5) quercetin: its action during pregnancy, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> pharmacological activities, clinical trials, and meta\u2010analysis; (6) quercetin intake during pregnancy; (7) other natural compounds tested during pregnancy; (8) potential problems with the use of quercetin; (9) safety profile of quercetin. Various studies have shown a beneficial effect of quercetin on vascular endothelial function and its antioxidative and anti\u2010inflammatory activity on cellular and tissue level. It is known that in animal models quercetin affects positively the development of embryo, fetus, and placenta. Because this flavonoid did not have teratogenic and abortive effect, it is generally recognized as safe. For this reason it should be appreciated and studied in the aspect of its potential use in the prevention and treatment of pregnancy\u2010induced hypertension among women in this risk group.<\/jats:p>","DOI":"10.1155\/2018\/7421489","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T23:34:16Z","timestamp":1543793656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy\u2010Induced Hypertension: Review of <i>In Vitro<\/i>, <i>In Vivo<\/i>, and Clinical Studies"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-3116","authenticated-orcid":false,"given":"Marcin","family":"O\u017carowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-6523","authenticated-orcid":false,"given":"Przemys\u0142aw \u0141.","family":"Miko\u0142ajczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Kujawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wielgus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Klejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Wolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Seremak-Mrozikiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,2]]},"reference":[{"key":"e_1_2_18_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S77344"},{"key":"e_1_2_18_2_2","first-page":"1","article-title":"Hypertensive Disorders of Pregnancy","volume":"3","author":"Mammaro A.","year":"2009","journal-title":"Journal of Prenatal Medicine"},{"key":"e_1_2_18_3_2","unstructured":"Pre-eclampsia 2018\/19 ICD-10-CM Codes at:https:\/\/www.icd10data.com\/ICD10CM\/Codes\/O00-O9A\/O10-O16\/O14."},{"key":"e_1_2_18_4_2","article-title":"Risk factors of pre-eclampsia\/eclampsia and its adverse outcomes in low- and middleIncome countries: a WHO secondary analysis","volume":"9","author":"Luanni V. 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