{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:13:27Z","timestamp":1768000407480,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,6,28]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the subsequent risks of urinary tract cancers among individuals with bladder pain syndrome\/interstitial cystitis (BPS\/IC), and gender differences, as well as the effect of associated comorbidity using a population-based administrative database in Taiwan.<jats:italic> Patients and Methods<\/jats:italic>. BPS\/IC subjects (10192) and their age- and sex-matched non-BPS\/IC control subjects (30576), who had no previous upper urinary tract cancer (UUC), bladder cancer (BC), and prostate cancer (PC), subsequently developed these disorders from the recruited date between 2002 and 2008 and the end of follow-up 2011. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent UUC, BC, and PC following a diagnosis of IC\/BPS. The effect of associated comorbidities was measured by Charlson Comorbidity Index (CCI). The risk of outcomes was assessed with Kaplan-Meier curves.<jats:italic> Results<\/jats:italic>. In the BPS\/IC subjects, 37 (0.36%) received a diagnosis of BC, and 22 (0.22%) received a diagnosis of UUC; both were significantly higher than the control group, 19 (0.06%) for BC and 30 (0.10%) for UUC. Cox proportional analysis revealed that the adjusted HR for BC and UUC during the follow-up period for patients with IC\/BPS was 5.44 (95% CI: 3.10-9.54) and 1.97 (95% CI: 1.13-3.45) than that of comparison subjects. The HRs went up to 5.66 (95% CI: 3.21-9.99) and 2.01 (95% CI: 1.14-3.55) after adjusted by Comorbidity Index (CCI). The male BPS\/IC patients have a higher adjusted HR for BC; however, female patients have a higher adjusted HR for both BC and UUC. The adjusted HR for PC has no difference between BPS\/IC and control group.<jats:italic> Conclusion<\/jats:italic>. Patients with BPS\/IC are at risk of developing BC in both males and females, and UUC in females. This result reminds physicians to evaluate the potential risk of subsequent development of BC and UUC among individuals with BPS\/IC.<\/jats:p>","DOI":"10.1155\/2018\/7495081","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T19:45:22Z","timestamp":1530215122000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Risk of Urinary Tract Carcinoma among Subjects with Bladder Pain Syndrome\/Interstitial Cystitis: A Nationwide Population-Based Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Ming Ping","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Urogynecology and Pelvic Floor Reconstruction, Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan"},{"name":"Center of General Education, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan"},{"name":"Department of Obstetrics and Gynecology, College of Medicine, Fu-Jen University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao Lun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-0520","authenticated-orcid":true,"given":"Shih Feng","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"},{"name":"Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"},{"name":"Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and 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