{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:55:52Z","timestamp":1740164152903,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2018,7,11]]},"abstract":"<jats:p><jats:italic>Cedecea neteri<\/jats:italic>, a member of the<jats:italic>Enterobacteriaceae<\/jats:italic>family, has only been identified as a human pathogen in a few previous clinical cases, thus complicating assessment of this organism\u2019s pathogenicity and medical relevance. Documented infections attributed to<jats:italic>C. neteri<\/jats:italic>primarily involved bacteremia in severely immunocompromised patients. We report a rare case of urinary catheter colonization by a multidrug-resistant<jats:italic>C. neteri<\/jats:italic>strain in a patient of advanced age with benign prostatic hyperplasia and other chronic comorbidities. This<jats:italic>C. neteri<\/jats:italic>isolate was resistant or intermediate to second-generation cephalosporins, penicillins, and certain<jats:italic>\u03b2<\/jats:italic>-lactamase inhibitor\/<jats:italic>\u03b2<\/jats:italic>-lactam combinations. Analysis of whole genome sequence information for a representative<jats:italic>C. neteri<\/jats:italic>strain indicated the presence of multiple open reading frames with sequence similarity to<jats:italic>\u03b2<\/jats:italic>-lactamases, including a chromosome-encoded AmpC<jats:italic>\u03b2<\/jats:italic>-lactamase and metallo-<jats:italic>\u03b2<\/jats:italic>-lactamases, consistent with the resistance phenotype of this bacterium. The presence of an AmpR homolog suggests that the<jats:italic>C. neteri<\/jats:italic><jats:italic>ampC<\/jats:italic>may be inducible in response to<jats:italic>\u03b2<\/jats:italic>-lactam exposure. Molecular insights into antibiotic resistance traits of this emerging opportunistic pathogen will be important for administering adequate antibiotic treatment to ensure favorable patient outcomes.<\/jats:p>","DOI":"10.1155\/2018\/7520527","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T23:45:42Z","timestamp":1531352742000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Urinary Catheter Colonization by Multidrug-Resistant<i>Cedecea neteri<\/i>in Patient with Benign Prostatic Hyperplasia"],"prefix":"10.1155","volume":"2018","author":[{"given":"Peter S.","family":"Ginn","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serina B.","family":"Tart","sequence":"additional","affiliation":[{"name":"Cape Fear Valley Health System, Fayetteville, NC 28304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-3555","authenticated-orcid":true,"given":"Stephen M.","family":"Sharkady","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-8359","authenticated-orcid":true,"given":"Dorothea K.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1099\/00207713-31-3-317"},{"volume-title":"Cedecea","year":"2005","first-page":"683","key":"2"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.jinf.2011.04.007"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.12659\/ajcr.889285"},{"issue":"2","key":"5","first-page":"204","volume":"18","year":"2008","journal-title":"European Journal of Dermatology"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/s0022-5347(17)51004-6"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.bjid.2013.03.003"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.3343\/alm.2015.35.2.266"},{"issue":"4","key":"9","first-page":"681","volume":"42","year":"2008","journal-title":"Mikrobiyoloji Bulteni"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1093\/jpids\/piw077"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/JCM.16.4.775-778.1982","volume":"16","year":"1982","journal-title":"Journal of Clinical Microbiology"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1136\/pgmj.71.833.179"},{"issue":"10","key":"13","first-page":"559","volume":"11","year":"1993","journal-title":"Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1128\/genomea.01339-14"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1007\/bf02014337"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.3109\/01676830.2016.1139597"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1128\/cmr.00036-08"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1128\/cmr.00064-16"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1128\/microbiolspec.VMBF-0016-2015"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1186\/1423-0127-16-109"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1128\/aac.03237-14"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1186\/s40793-017-0255-1"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/7520527.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/7520527.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2018\/7520527.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:44:06Z","timestamp":1604598246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2018\/7520527\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":22,"alternative-id":["7520527","7520527"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7520527","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}