{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:34Z","timestamp":1787017834548,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T00:00:00Z","timestamp":1545523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["SAF 2011-23636"],"award-info":[{"award-number":["SAF 2011-23636"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI11\/0443"],"award-info":[{"award-number":["PI11\/0443"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF 2011-23636"],"award-info":[{"award-number":["SAF 2011-23636"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI11\/0443"],"award-info":[{"award-number":["PI11\/0443"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RecerCaixa","award":["SAF 2011-23636"],"award-info":[{"award-number":["SAF 2011-23636"]}]},{"name":"RecerCaixa","award":["PI11\/0443"],"award-info":[{"award-number":["PI11\/0443"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["SAF 2011-23636"],"award-info":[{"award-number":["SAF 2011-23636"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI11\/0443"],"award-info":[{"award-number":["PI11\/0443"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018,12,23]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinally\u2014at birth and at age 4 months\u2014in 86 term infants born appropriate (AGA), small (SGA), or large for gestational age (LGA).\n                    <jats:italic>Results<\/jats:italic>\n                    . Cord blood NGF levels in SGA newborns were higher than those in AGA newborns (1.41\u2009\u00b1\u20090.2\u2009pg\/mL vs. 0.66\u2009\u00b1\u20090.1\u2009pg\/mL;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.02<\/mml:mn>\n                    <\/mml:math>\n                    ) and not different from those in LGA neonates (0.79\u2009\u00b1\u20090.2\u2009pg\/mL). At age 4 months, SGA-breastfed infants showed the highest NGF concentrations (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.02<\/mml:mn>\n                    <\/mml:math>\n                    and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.01<\/mml:mn>\n                    <\/mml:math>\n                    vs. AGA and SGA-formula-fed infants, respectively), while LGA infants depicted a marginal increase. NGF levels in cord blood correlated negatively with the ponderal index at birth (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>r<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                    <\/mml:math>\n                    \u22120.36;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.0008<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Circulating NGF is related to both prenatal growth and early postnatal nutrition. The maintenance of increased NGF concentrations in SGA-breastfed infants at age 4 months might be a potential mechanism to counterbalance potential risks for developing cognitive and psychomotor disadvantages.\n                  <\/jats:p>","DOI":"10.1155\/2018\/7562702","type":"journal-article","created":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T18:31:32Z","timestamp":1545589892000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Nerve Growth Factor Levels in Term Human Infants: Relationship to Prenatal Growth and Early Postnatal Feeding"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-7501","authenticated-orcid":true,"given":"David","family":"S\u00e1nchez-Infantes","sequence":"first","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Cereijo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"P\u00e9rez-Cruz","sequence":"additional","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Villarroya","sequence":"additional","affiliation":[{"name":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), ISCIII, Madrid, 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