{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:32:59Z","timestamp":1790746379993,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Experimental muscle pain inhibits corticomotor excitability (CE) of upper limb muscles. It is unknown if this inhibition affects overlapping muscle representations within the primary motor cortex to the same degree. This study explored CE changes of the first dorsal interosseus (FDI) and extensor carpi radialis (ECR) muscles in response to muscle pain. Participants (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>13<\/mml:mn><\/mml:math>) attended two sessions (\u226548 hours in-between). Hypertonic saline was injected in the ECR (session one) or the FDI (session two) muscle. CE, assessed by transcranial magnetic stimulation (TMS) motor-evoked potentials (MEPs), was recorded at baseline, during pain, and twenty minutes postinjection together with pain intensity ratings. Pain intensity ratings did not differ between the two pain sites (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.19<\/mml:mn><\/mml:math>). In response to FDI muscle pain, the MEPs of the FDI muscle were reduced at 2 and 4\u2009min postinjection (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>), but not after ECR muscle pain. No significant MEP change was detected for the ECR muscle (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.62<\/mml:mn><\/mml:math>). No associations between MEPs and pain intensity were found (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.2<\/mml:mn><\/mml:math>). The present results indicate that the output from overlapping cortical representations of two muscles differentially adapts to acute muscle pain.<\/jats:p>","DOI":"10.1155\/2018\/7589601","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T19:32:22Z","timestamp":1524425542000},"page":"1-9","source":"Crossref","is-referenced-by-count":21,"title":["Differential Corticomotor Excitability Responses to Hypertonic Saline-Induced Muscle Pain in Forearm and Hand Muscles"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-7408","authenticated-orcid":true,"given":"Dennis B.","family":"Larsen","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Aalborg, 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