{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:49:30Z","timestamp":1740167370872,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conte Center","award":["MH-094268"],"award-info":[{"award-number":["MH-094268"]}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["MH-094268"],"award-info":[{"award-number":["MH-094268"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2018,12,2]]},"abstract":"<jats:p>Infection with the protozoan parasite,<jats:italic>Toxoplasma gondii<\/jats:italic>(<jats:italic>T. gondii<\/jats:italic>), was linked to several psychiatric disorders. The exact mechanisms of a hypothesized contribution of<jats:italic>T. gondii<\/jats:italic>infection are poorly understood, and it appears that only a subset of seropositive individuals go on to develop a mental illness, suggesting genetic vulnerability. In order to stimulate mechanistic studies of how exposure to<jats:italic>T. gondii<\/jats:italic>could interact with genetic predisposition to psychiatric disorders, we have generated and characterized a mouse model of chronic<jats:italic>T. gondii<\/jats:italic>infection in BALB\/c mice with inducible forebrain neuronal expression of a C-terminus truncated dominant-negative form of disrupted-in-schizophrenia 1 (DN-DISC1). In this gene-environment interaction (GxE) model, exposing control and DN-DISC1 male and female mice to<jats:italic>T. gondii<\/jats:italic>produced sex-dependent abnormalities in locomotor activity and prepulse inhibition of the acoustic startle. No genotype- or sex-dependent effects were found on levels of anti-Toxoplasma IgG antibodies or anti-NMDAR or C1q antibodies. Our work demonstrates that a psychiatric genetic risk factor, DN-DISC1, modulates the neurobehavioral effects of chronic<jats:italic>T. gondii<\/jats:italic>infection in a sex-dependent manner. The present<jats:italic>T. gondii<\/jats:italic>model of GxE provides a valuable experimental system for future mechanistic studies and evaluation of new treatments.<\/jats:p>","DOI":"10.1155\/2018\/7590958","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T23:34:19Z","timestamp":1543793659000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["A New<i>T. gondii<\/i>Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease"],"prefix":"10.1155","volume":"2018","author":[{"given":"Geetha","family":"Kannan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"},{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-4552","authenticated-orcid":true,"given":"Emese","family":"Prandovszky","sequence":"additional","affiliation":[{"name":"Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Severance","sequence":"additional","affiliation":[{"name":"Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[{"name":"Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-6559","authenticated-orcid":true,"given":"Mikhail V.","family":"Pletnikov","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"},{"name":"The Solomon H. 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