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The nuclear transcription factor erythroid 2\u2010related factor (Nrf2) and the nuclear factor <jats:italic>\u03ba<\/jats:italic>B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) play central roles in regulation of oxidative stress and inflammation and thus are targets for developing agents against oxidative stress\u2010 and inflammation\u2010related diseases. Our previous study indicated that the EtOH extract of <jats:italic>Litsea garrettii<\/jats:italic> protected human bronchial epithelial cells against oxidative insult via the activation of Nrf2. In the present study, a systemic phytochemical investigation of <jats:italic>L. garrettii<\/jats:italic> led to the isolation of twenty\u2010one chemical ingredients, which were further evaluated for their inhibitions on oxidative stress and inflammation using NAD(P)H:quinone reductase (QR) assay and nitric oxide (NO) production assay. Of these ingredients, 3\u2010methoxy\u20105\u2010pentyl\u2010phenol (MPP, 5) was identified as an Nrf2 activator and an NF\u2010<jats:italic>\u03ba<\/jats:italic>B inhibitor. Further studies demonstrated the following: (i) MPP upregulated the protein levels of Nrf2, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate\u2010cysteine ligase regulatory subunit (GCLM); enhanced the nuclear translocation and stabilization of Nrf2; and inhibited arsenic [As(III)]\u2010induced oxidative insult in normal human lung epithelial Beas\u20102B cells. And (ii) MPP suppressed the nuclear translocation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65 subunit; inhibited the lipopolysaccharide\u2010 (LPS\u2010) stimulated increases of NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65 subunit, COX\u20102, iNOS, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and IL\u20101<jats:italic>\u03b2<\/jats:italic>; and blocked the LPS\u2010induced biodegrade of I<jats:italic>\u03ba<\/jats:italic>B\u2010<jats:italic>\u03b1<\/jats:italic> in RAW 264.7 murine macrophages. Taken together, MPP displayed potential preventive effects against inflammation\u2010 and oxidative stress\u2010related diseases.<\/jats:p>","DOI":"10.1155\/2018\/7616852","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T23:32:53Z","timestamp":1521588773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ingredients from <i>Litsea garrettii<\/i> as Potential Preventive Agents against Oxidative Insult and Inflammatory 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