{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:54:11Z","timestamp":1777402451514,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Technology Department of Zhejiang Province","award":["2015C33257"],"award-info":[{"award-number":["2015C33257"]}]},{"name":"Science Technology Department of Zhejiang Province","award":["15yw02-5"],"award-info":[{"award-number":["15yw02-5"]}]},{"name":"Science Technology Department of Zhejiang Province","award":["1701KY33"],"award-info":[{"award-number":["1701KY33"]}]},{"name":"Science Technology Department of Zhejiang Province","award":["1801ky41"],"award-info":[{"award-number":["1801ky41"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["2015C33257"],"award-info":[{"award-number":["2015C33257"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["15yw02-5"],"award-info":[{"award-number":["15yw02-5"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1701KY33"],"award-info":[{"award-number":["1701KY33"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1801ky41"],"award-info":[{"award-number":["1801ky41"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["2015C33257"],"award-info":[{"award-number":["2015C33257"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["15yw02-5"],"award-info":[{"award-number":["15yw02-5"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1701KY33"],"award-info":[{"award-number":["1701KY33"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1801ky41"],"award-info":[{"award-number":["1801ky41"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["2015C33257"],"award-info":[{"award-number":["2015C33257"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["15yw02-5"],"award-info":[{"award-number":["15yw02-5"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1701KY33"],"award-info":[{"award-number":["1701KY33"]}]},{"name":"Science and Technology Agency of Taizhou City","award":["1801ky41"],"award-info":[{"award-number":["1801ky41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2018,10,30]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>. In patients with nasopharyngeal carcinoma (NPC), local treatment failure and distant metastasis contribute largely to poor outcomes. The nasopharynx is an important lymphoid tissue, and NPC tumourigenesis and development are partly attributed to immune system disorders. Human leukocyte antigen F (HLA-F) has shown a close correlation with NPC in many genome-wide association studies (GWASs). However, clinical studies rarely explore the relationship of HLA-F expression with the clinical parameters and outcomes in patients with NPC.<jats:italic>Methods<\/jats:italic>. In this study, we used immunohistochemistry to evaluate HLA-F expression in 74 paraffin-embedded NPC tissue sections and then analysed the association between HLA-F expression and clinical parameters and outcomes. The plasma concentration of soluble HLA-F (sHLA-F) in NPC patients and normal controls was also detected, via enzyme-linked immunosorbent assay (ELISA).<jats:italic>Results<\/jats:italic>. Low, moderate, and high HLA-F expression levels were observed in 47.3% (35\/74), 35.1% (26\/74), and 17.6% (13\/74), respectively, of the tissue samples. HLA-F expression showed a significant correlation with local recurrence (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.037<\/mml:mn><\/mml:math>) and distant metastasis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:math>) and was also an independent factor for local recurrence-free survival (LRFS;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.016<\/mml:mn><\/mml:math>) and distant metastasis-free survival (DMFS;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>). Although the mean concentration of plasma sHLA-F in the NPC patients was higher than that in the normal controls (13.63\u2009pg\/ml vs. 10.06\u2009pg\/ml), no statistical significance was observed (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.118<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Our study provides the first evidence that high HLA-F expression is associated with NPC local recurrence and distant metastasis and may be regarded as a poor prognostic factor for NPC patients. Additional studies using larger sample sizes may be necessary to determine whether sHLA-F is a feasible NPC diagnostic indicator.<\/jats:p>","DOI":"10.1155\/2018\/7691704","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T19:31:33Z","timestamp":1540927893000},"page":"1-8","source":"Crossref","is-referenced-by-count":13,"title":["High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-1201","authenticated-orcid":true,"given":"Bo","family":"Wu","sequence":"first","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Yang","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenpeng","family":"Ying","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsheng","family":"Lu","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Lv","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huacai","family":"Xiong","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-0295","authenticated-orcid":true,"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"The Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, 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