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We report the case of an 8\u2010year\u2010old boy with a typical clinical picture of Noonan syndrome with a de novo germline mutation of PTPN11 (c.854 T&gt;C). During his follow\u2010up, the patient developed multifocal pigmented villonodular synovitis which first affected the left knee and shortly after both elbows.<\/jats:p>","DOI":"10.1155\/2018\/7698052","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T18:49:12Z","timestamp":1544122152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-4200","authenticated-orcid":false,"given":"Othmane","family":"Miri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-7998","authenticated-orcid":false,"given":"Philippe","family":"Lysy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naima","family":"Loucheur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Gayito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-3970","authenticated-orcid":false,"given":"Pierre Louis","family":"Docquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng772"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.24.1.9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.117197"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400208"},{"key":"e_1_2_6_5_2","first-page":"731","article-title":"Pigmented villonodular synovitis, bursitis and tenosynovitis","volume":"31","author":"Jaffe H. 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