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Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.<\/jats:p>","DOI":"10.1155\/2018\/7806435","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T19:32:31Z","timestamp":1529955151000},"page":"1-16","source":"Crossref","is-referenced-by-count":66,"title":["Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications"],"prefix":"10.1155","volume":"2018","author":[{"given":"Bou-Yue","family":"Peng","sequence":"first","affiliation":[{"name":"School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, Taiwan"},{"name":"Department of Dentistry, Taipei Medical University Hospital, Taipei City 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Ceramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang 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