{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:02:03Z","timestamp":1787929323659,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High-Technology Research and Development Program of China","award":["2012AA02A509"],"award-info":[{"award-number":["2012AA02A509"]}]},{"name":"National High-Technology Research and Development Program of China","award":["2016YFC1304901"],"award-info":[{"award-number":["2016YFC1304901"]}]},{"name":"National High-Technology Research and Development Program of China","award":["D131100005313008"],"award-info":[{"award-number":["D131100005313008"]}]},{"name":"National High-Technology Research and Development Program of China","award":["Z141100007414002"],"award-info":[{"award-number":["Z141100007414002"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2012AA02A509"],"award-info":[{"award-number":["2012AA02A509"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC1304901"],"award-info":[{"award-number":["2016YFC1304901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["D131100005313008"],"award-info":[{"award-number":["D131100005313008"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["Z141100007414002"],"award-info":[{"award-number":["Z141100007414002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["2012AA02A509"],"award-info":[{"award-number":["2012AA02A509"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["2016YFC1304901"],"award-info":[{"award-number":["2016YFC1304901"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["D131100005313008"],"award-info":[{"award-number":["D131100005313008"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["Z141100007414002"],"award-info":[{"award-number":["Z141100007414002"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["2012AA02A509"],"award-info":[{"award-number":["2012AA02A509"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["2016YFC1304901"],"award-info":[{"award-number":["2016YFC1304901"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["D131100005313008"],"award-info":[{"award-number":["D131100005313008"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["Z141100007414002"],"award-info":[{"award-number":["Z141100007414002"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1\u2009:\u20092) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>] and healthy controls [0.249 (0.049, 1.234), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.019<\/mml:mn><\/mml:math>]. The area under the curve of the receiver operating characteristic curve for miR-122 to discriminate HNF1A-DM and T2DM was 0.687 (95% CI: 0.52\u20130.86, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.07<\/mml:mn><\/mml:math>). There was no difference in serum miR-122 among HNF1A-DM, GCK-DM, MDM, and T1DM patients. Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients.<\/jats:p>","DOI":"10.1155\/2018\/7842064","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T23:42:01Z","timestamp":1533166921000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xiuting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-0543","authenticated-orcid":true,"given":"Xiaoling","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-6727","authenticated-orcid":true,"given":"Xianghai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-8245","authenticated-orcid":true,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-4937","authenticated-orcid":true,"given":"Xueyao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-2168","authenticated-orcid":true,"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People\u2019s Hospital, Peking University Diabetes Center, Beijing, 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0942-y"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.333"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/384455a0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/86871"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.034"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02575-07"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00809-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4161\/rna.1.2.1066"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178178"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20712"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0731"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1354"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.211"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23875"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23818"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.04.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.08.038"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/384458a0"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw146"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M004812"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.12b.2353"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.01.002"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.005"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25960"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.02.005"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02720.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M052969"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.024"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.012"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031552"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-0932-4"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24538"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.147850"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2018\/7842064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2018\/7842064.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2018\/7842064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T22:49:20Z","timestamp":1589928560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jdr\/2018\/7842064\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":36,"alternative-id":["7842064","7842064"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7842064","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}