{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:52:24Z","timestamp":1764251544119,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"],"award-info":[{"award-number":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"],"award-info":[{"award-number":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"],"award-info":[{"award-number":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"],"award-info":[{"award-number":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"],"award-info":[{"award-number":["CMRPG-370444","290262","NSC100-2325-B-182-008","NSC 103-2314-B-182A-006","NMRPD1A0842"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2018,6,19]]},"abstract":"<jats:p>The unidentified presence of uterine smooth muscle malignancies poses a tremendous risk in women planning surgery for presumed benign leiomyomas. We sought to investigate whether preoperative FDG PET may be useful to identify leiomyosarcomas (LMS) and smooth muscle tumors of uncertain malignant potential (STUMP). <jats:italic>Methods<\/jats:italic>. We investigated patients with rapidly growing uterine masses which were suspected of being malignant on ultrasound or MRI. Among the 21 patients who underwent FDG PET, we identified 7 LMS, 1 STUMP, and 13 leiomyomas. PET-derived parameters and FDG uptake patterns were analyzed retrospectively. <jats:italic>Results<\/jats:italic>. The SUV<jats:sub>max<\/jats:sub> values of LMS\/STUMP (range: 3.7\u201311.8) were significantly higher than those observed in leiomyomas (range: 2.0\u20139.4; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:mrow><\/mml:math>) despite a significant overlap. The metabolic tumor\/necrosis ratio was significantly higher in LMS\/STUMP than in leiomyomas (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), with no significant intergroup overlaps. All LMS\/STUMP revealed a characteristic pattern of FDG uptake, identifying a specific \u201chollow ball\u201d sign (corresponding to areas of coagulative tumor necrosis). In contrast, this sign was invariably absent in patients with leiomyomas. <jats:italic>Conclusion<\/jats:italic>. The characteristic FDG uptake pattern instead of SUV on PET images allows identifying LMS\/STUMP in patients with rapidly growing uterine masses, avoiding the deleterious consequences of regular surgery for presumed benign leiomyomas.<\/jats:p>","DOI":"10.1155\/2018\/7890241","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T19:37:27Z","timestamp":1529437047000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["Presurgical Identification of Uterine Smooth Muscle Malignancies through the Characteristic FDG Uptake Pattern on PET Scans"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6841-4590","authenticated-orcid":true,"given":"Kung-Chu","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-7983","authenticated-orcid":true,"given":"Yu-Hua","family":"Dean Fang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-1058","authenticated-orcid":true,"given":"Gigin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shir-Hwa","family":"Ueng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-I","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyong-Huey","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Yen","family":"Chueh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, 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