{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:46:14Z","timestamp":1758933974765,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The aim of this study was to determine the role of adjuvant endovaginal brachytherapy HDR (High Dose Rate) or observation, as well as identification of risk factors of tumor recurrence. The study included 178 women after radical hysterectomy. All patients belonged to the group of low- and medium-risk stage I FIGO. Analysis consisted of 3-, 5-, and 10-year OS, DFS, and LRFS in both groups. Follow-up was more than 6.5 years. The 5-OS, 5-DFS, and 5-LRFS were 93%, 96%, and 98% in the treated group and 95%, 94%, and 96% in the observed group, respectively. These differences were not statistically significant. There was a statistically significant difference in 5-OS in the treated group, between low- and medium-risk subgroups (100% versus 87.55%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.018<\/mml:mn><\/mml:math>). There was a better prognosis among the patients with FIGO IA compared to FIGO IB (5-DFS, 97 versus 86%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.047<\/mml:mn><\/mml:math>). Among the risk factors, there were only statistically significant differences in the 5-OS, between the ages of \u2264 70 years and &gt;70 years. Use of brachytherapy may affect the reduction in the number of local recurrences at the vaginal stump (6% versus 2%). This is particularly noticeable in the low-risk subgroup (9% versus 0%).<\/jats:p>","DOI":"10.1155\/2018\/7924153","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:35:30Z","timestamp":1519238130000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Retrospective Analysis of Intravaginal Brachytherapy in Adjuvant Treatment of Early Endometrial Cancer"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-5289","authenticated-orcid":true,"given":"Pawe\u0142","family":"Cisek","sequence":"first","affiliation":[{"name":"Department of Oncology, Medical University of Lublin, Jaczewskiego 7, Lublin, Poland"},{"name":"Department of Brachytherapy, St. John\u2019s Oncology Center of Lublin, Jaczewskiego 7, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Kieszko","sequence":"additional","affiliation":[{"name":"Department of Brachytherapy, St. John\u2019s Oncology Center of Lublin, Jaczewskiego 7, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Kordzi\u0144ska-Cisek","sequence":"additional","affiliation":[{"name":"Department of Oncology, Medical University of Lublin, Jaczewskiego 7, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Kutarska","sequence":"additional","affiliation":[{"name":"Department of Gynecology, St. John\u2019s Oncology Center of Lublin, Jaczewskiego 7, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmi\u0142a","family":"Grzybowska-Szatkowska","sequence":"additional","affiliation":[{"name":"Department of Oncology, Medical University of Lublin, Jaczewskiego 7, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S119125"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.01.023"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.048"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02139-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61767-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01332.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm066"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181a6c9df"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5155"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5526"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00427-7"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.054"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.06.027"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-015-1463-z"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.lba5503"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.03.024"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2008.01198.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.026"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00156.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00085-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01672-6"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2017.07.003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2016.10.001"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.111"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6494"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.03.554"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.03.009"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.04.010"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2014.09.003"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.10.009"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1454-9"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31828c85c6"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01150.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4583-3"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7924153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7924153.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/7924153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:35:30Z","timestamp":1519238130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/7924153\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":34,"alternative-id":["7924153","7924153"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7924153","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2018]]}}}