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Neuroinflammation was identified to be an important contributor to PD pathogenesis with the hallmark of microglia activation. Tetrahydroxystilbene glucoside (TSG) was the main active component extracted from <jats:italic>Polygonum multiflorum<\/jats:italic> and held amounts of pharmacological activities including antioxidant, free radical\u2010scavenging, anti\u2010inflammation, and cardioprotective properties. Recent studies demonstrated that TSG exerted neuroprotection from several neurodegenerative disease models. However, the underlying mechanisms were not completely elucidated. In the present study, rat nigral stereotaxic injection of 6\u2010hydroxydopamine\u2010 (6\u2010OHDA\u2010) elicited DA neuronal injury was performed to investigate TSG\u2010mediated neuroprotection on DA neurons. In addition, primary rat midbrain neuron\u2010glia cocultures were applied to explore the mechanisms underlying TSG\u2010exerted neuroprotection. Results showed that daily intraperitoneal injection of TSG for 14 consecutive days significantly protected DA neurons from 6\u2010OHDA\u2010induced neurotoxicity and suppressed microglia activation. Similar neuroprotection was shown in primary neuron\u2010glia cocultures. <jats:italic>In vitro<\/jats:italic> studies further demonstrated that TSG inhibited microglia activation and subsequent release of proinflammatory factors. Moreover, TSG\u2010mediated neuroprotection was closely related with the inactivation of mitogen\u2010activated protein kinase (MAPK) signaling pathway. Together, TSG protects DA neurons from 6\u2010OHDA\u2010induced neurotoxicity via the inhibition of microglia\u2010elicited neuroinflammation. These findings suggest that TSG might hold potential therapeutic effects on PD.<\/jats:p>","DOI":"10.1155\/2018\/7927568","type":"journal-article","created":{"date-parts":[[2018,1,14]],"date-time":"2018-01-14T23:31:47Z","timestamp":1515972707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6\u2010OHDA\u2010Induced Dopamine 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