{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:22:28Z","timestamp":1785583348533,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670722"],"award-info":[{"award-number":["81670722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471004"],"award-info":[{"award-number":["81471004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JSZK2015A02"],"award-info":[{"award-number":["JSZK2015A02"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670722"],"award-info":[{"award-number":["81670722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471004"],"award-info":[{"award-number":["81471004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JSZK2015A02"],"award-info":[{"award-number":["JSZK2015A02"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Disciplines Development of Shanghai Jinshan District","award":["81670722"],"award-info":[{"award-number":["81670722"]}]},{"name":"Key Disciplines Development of Shanghai Jinshan District","award":["81471004"],"award-info":[{"award-number":["81471004"]}]},{"name":"Key Disciplines Development of Shanghai Jinshan District","award":["JSZK2015A02"],"award-info":[{"award-number":["JSZK2015A02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,6,11]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To date, studies have shown that polymorphisms in an autophagy-related gene,<jats:italic> IRGM<\/jats:italic>, are linked with different diseases, especially autoimmune diseases. The present study aimed to examine the roles of<jats:italic> IRGM<\/jats:italic> polymorphisms in autoimmune thyroid diseases (AITD).<jats:italic> Methods<\/jats:italic>. Three polymorphisms in<jats:italic> IRGM<\/jats:italic> gene (rs10065172, rs4958847, and rs13361189) were genotyped in 1569 participants (488 with Graves\u2019 disease, 292 with Hashimoto\u2019s thyroiditis, and 789 healthy controls) using PCR-based ligase detection reaction method. Gene-disease associations were evaluated for the three SNPs.<jats:italic> Results<\/jats:italic>. T allele of rs10065172, A allele of rs4958847, and C allele of rs13361189 were all higher in Graves\u2019 disease patients than controls, and the ORs were OR = 1.207 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.022<\/mml:mn><\/mml:math>), OR = 1.207 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.027<\/mml:mn><\/mml:math>), and OR = 1.200 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.027<\/mml:mn><\/mml:math>), respectively. After adjusting for sex and age, rs10065172 and rs13361189 were still associated with GD under both the allele model and dominant model, and the adjusted ORs for rs10065172 were 1.20 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">33<\/mml:mn><\/mml:math>) and 1.33 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><mml:mn fontstyle=\"italic\">4<\/mml:mn><\/mml:math>), while the adjusted ORs for rs13361189 were 1.19 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">42<\/mml:mn><\/mml:math>) and 1.33 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><mml:mn fontstyle=\"italic\">6<\/mml:mn><\/mml:math>), respectively. No significant difference was found between Hashimoto\u2019s thyroiditis patients and controls. Haplotype analysis found that CTA frequency was distinguishingly higher in Graves\u2019 disease patients (OR = 1.195, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.030<\/mml:mn><\/mml:math>). The frequency of TCG haplotype was distinguishingly lower in AITD and Graves\u2019 disease patients (OR = 0.861, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.044<\/mml:mn><\/mml:math>; OR = 0.816, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.017<\/mml:mn><\/mml:math>).<jats:italic> Conclusions<\/jats:italic>. Our study reveals<jats:italic> IRGM<\/jats:italic> as a susceptibility gene of AITD and Graves\u2019 disease for the first time.<\/jats:p>","DOI":"10.1155\/2018\/7959707","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T19:35:11Z","timestamp":1528745711000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Polymorphisms in Autophagy-Related Gene<i> IRGM<\/i> Are Associated with Susceptibility to Autoimmune Thyroid Diseases"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-3107","authenticated-orcid":true,"given":"Qiu-ming","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology, Weinan Central Hospital, Shaanxi Province 714000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-1580","authenticated-orcid":true,"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-qing","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, 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