{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:25:06Z","timestamp":1787505906097,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy at Ho Chi Minh City"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018,7,5]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . HLA-B\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:msup>\n                        <mml:mrow\/>\n                        <mml:mrow>\n                          <mml:mo>\u2217<\/mml:mo>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients.\n                    <jats:italic>Methods<\/jats:italic>\n                    . HLA-B\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:msup>\n                        <mml:mrow\/>\n                        <mml:mrow>\n                          <mml:mo>\u2217<\/mml:mo>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls.\n                    <jats:italic>Results<\/jats:italic>\n                    . Frequency of HLA-B\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:msup>\n                        <mml:mrow\/>\n                        <mml:mrow>\n                          <mml:mo>\u2217<\/mml:mo>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR\u2009=\u200928.6, 95% CI\u2009=\u20096.8\u2013120.2).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . HLA-B\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:msup>\n                        <mml:mrow\/>\n                        <mml:mrow>\n                          <mml:mo>\u2217<\/mml:mo>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.\n                  <\/jats:p>","DOI":"10.1155\/2018\/7965346","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T19:35:21Z","timestamp":1530819321000},"page":"1-5","source":"Crossref","is-referenced-by-count":18,"title":["Association of HLA-B\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:msup>\n                        <mml:mrow\/>\n                        <mml:mrow>\n                          <mml:mo>\u2217<\/mml:mo>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mai Phuong","family":"Thao","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Vo Anh","family":"Tuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Gia Hoang","family":"Linh","sequence":"additional","affiliation":[{"name":"Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam","family":"Van Hoang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Huu","family":"Hen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Tuyet","family":"Hoa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Anh","family":"Vu","sequence":"additional","affiliation":[{"name":"Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-6390","authenticated-orcid":true,"given":"Do Duc","family":"Minh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cho Ray Hospital, Ho Chi Minh City, Vietnam"},{"name":"Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0801880"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.7.4.481"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2569"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.8.455"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009717"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4848"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8633"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.309"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12350-2"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00113-3"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.4.475"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0439"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-493-7_9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00982.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb04130.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.144.8.1687"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.019"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.1998.00091.x"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-5-199603010-00005"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/7965346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/7965346.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/7965346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T19:35:25Z","timestamp":1530819325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2018\/7965346\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":20,"alternative-id":["7965346","7965346"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7965346","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}