{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:57:55Z","timestamp":1779195475619,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-line treatment for seminoma with isolated lymph node metastasis to the retroperitoneum. Four retrospective studies have shown promising results when surgery is performed for seminomas with low-volume retroperitoneal metastases. To better determine if RPLND can be recommended as a primary treatment option, two prospective clinical trials (SEMS and PRIMETEST) are underway. This review will examine the literature, discuss the benefits\/limitations of RPLND, and compare the methodologies of the two ongoing clinical trials.<\/jats:p>","DOI":"10.1155\/2018\/7978958","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T18:35:56Z","timestamp":1517510156000},"page":"1-5","source":"Crossref","is-referenced-by-count":17,"title":["Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-9923","authenticated-orcid":true,"given":"Brian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Urology, Loma Linda University, 11234 Anderson Street Room A-560, Loma Linda, CA 92374, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"University of Southern California Institute of Urology, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds579"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.05.205"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90475-w"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.08.014"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-017-1622-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.02.024"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2015.04.006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3109\/00365599709030619"},{"key":"9","year":"2010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-005-4793-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2015.01.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.07.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.02.2408"},{"key":"14","year":"2017"},{"key":"15","year":"2017"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)32754-4"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000060960.18092.54"}],"container-title":["Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2018\/7978958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2018\/7978958.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/au\/2018\/7978958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T18:35:56Z","timestamp":1517510156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/au\/2018\/7978958\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":17,"alternative-id":["7978958","7978958"],"URL":"https:\/\/doi.org\/10.1155\/2018\/7978958","relation":{},"ISSN":["1687-6369","1687-6377"],"issn-type":[{"value":"1687-6369","type":"print"},{"value":"1687-6377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}