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We report the case of a 41-year-old man with HIV (CD4 of 144\u2009cells\/dL) and HCV with hematochezia due to tuberculosis in the ileocecal valve and descending colon and CMV tissue invasive disease in the esophagus and descending colon. Coinfection among tuberculosis and cytomegalovirus in the gastrointestinal tract was described only once in a patient with a recent diagnosis of HIV that affected the distal ileum and ascending colon. We will discuss the peculiarities of the case and the behavior of the immune system in the face of simultaneous opportunistic infections. This is a challenging scenario that has scarce publications and is of great clinical importance.<\/jats:p>","DOI":"10.1155\/2018\/8047892","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T19:34:31Z","timestamp":1528745671000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Gastrointestinal CMV Disease and Tuberculosis in an AIDS Patient: Synergistic Interaction between Opportunistic Coinfections"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-5810","authenticated-orcid":true,"given":"Miri\u00e3","family":"Boaretto Teixeira Fernandes","sequence":"first","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Afonso","family":"Nogueira Mois\u00e9s Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro (UNIRIO), 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