{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:49:52Z","timestamp":1785797392302,"version":"3.56.0"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To review the available literature on medication-related osteonecrosis of the jaw (MRONJ) associated with antiangiogenics in antiresorptive-na\u00efve individuals.<jats:italic> Methods<\/jats:italic>. A literature search was performed using MEDLINE via PubMed, EMBASE, and Web of Science in December 2017.<jats:italic> Results<\/jats:italic>. We identified reports describing a total of 35 antiresorptive drugs-na\u00efve patients who developed antiangiogenic-related MRONJ. The mean age of these patients was 59.06 years and the F\u2009:\u2009M ratio was 4\u2009:\u20095. The most common underlying disease was metastatic renal cell cancer. Pain to the mandible was the most common complaint (34.29%) and the majority of patients presented with bone exposure. The mean duration of intravenous and oral antiangiogenics before MRONJ development was 6.5 and 16.72 months, respectively. The most common additional risk factor was dental extraction (37.14%). Almost half of the MRONJ patients (48.57%) received surgical treatment. 18 patients (62.06%) were reported to have disease resolution within an average time of 6.75 months.<jats:italic> Conclusion.<\/jats:italic> MRONJ associated with antiangiogenic therapy in antiresorptive-na\u00efve patients is a rare but potentially serious adverse effect. Available data suggests that there might be notable differences between MRONJ associated with antiangiogenics and antiresorptives; however, further prospective well-designed studies are required.<\/jats:p>","DOI":"10.1155\/2018\/8071579","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T19:32:54Z","timestamp":1524511974000},"page":"1-14","source":"Crossref","is-referenced-by-count":74,"title":["Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Na\u00efve Patient: A Comprehensive Review of the Literature"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-3737","authenticated-orcid":true,"given":"Kununya","family":"Pimolbutr","sequence":"first","affiliation":[{"name":"UCL Eastman Dental Institute, London, UK"},{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, 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