{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:43:19Z","timestamp":1740170599879,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T00:00:00Z","timestamp":1531008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["00179906"],"award-info":[{"award-number":["00179906"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MH CZ\u2014DRO","award":["00179906"],"award-info":[{"award-number":["00179906"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2018,7,8]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The poor metabolic control in type 1 diabetes mellitus (T1D) has a negative impact on the developing brain. Hyperglycemia and glycemic fluctuations disrupt mainly executive functions. To assess a hypothesized deficit of the executive functions, we evaluated visual processing and reaction time in an oddball task. <jats:italic>Methods<\/jats:italic>. Oddball visual event-related potentials (ERPs), reaction time, and pattern-reversal visual evoked potentials (VEPs) were examined in a cohort of twenty-two 12- to 18-year-old T1D patients without diabetic retinopathy at normal glycemia and in nineteen 10- to 21-year-old healthy controls. <jats:italic>Results<\/jats:italic>. The P100 peak time of the VEPs was significantly prolonged in T1D patients compared with the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>). In contrast to the deteriorated sensory response, the area under the curve of the P3b component of the ERPs was significantly larger (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.035<\/mml:mn><\/mml:math>) in patients, while reaction time in the same task did not differ between groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.713<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. The deterioration on a sensory level, enhanced activity during cognitive processing, and balanced behavioral response support the view that neuroplasticity counterbalances the neural impairment by enhanced cognitive processing to achieve normal behavioral performance in T1D adolescents.<\/jats:p>","DOI":"10.1155\/2018\/8105407","type":"journal-article","created":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T19:33:41Z","timestamp":1531078421000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Neurophysiological Evidence for a Compensatory Activity during a Simple Oddball Task in Adolescents with Type 1 Diabetes Mellitus"],"prefix":"10.1155","volume":"2018","author":[{"given":"Tereza","family":"Vitvarov\u00e1","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech 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