{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:33:28Z","timestamp":1788982408056,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T00:00:00Z","timestamp":1545523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Saud University","award":["RG-1436-015"],"award-info":[{"award-number":["RG-1436-015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,12,23]]},"abstract":"<jats:p>Diabetes is an increasingly common metabolic disorder with high comorbidity and societal and personal costs. Insulin replacement therapy is limited by a lack of oral bioavailability. Recent studies suggest vanadium has therapeutic potential. A newly synthesized complex between oxidovanadium (IV) and orotic acid (OAH<jats:sub>3<\/jats:sub>), [(OAH<jats:sub>1<\/jats:sub>)(VO)(NH<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub>].3H<jats:sub>2<\/jats:sub>O, was characterized using spectroscopic and thermogravimetric techniques.<jats:italic>In vivo<\/jats:italic>potential was assessed in a streptozocin-induced rat model of diabetes. OAH<jats:sub>3<\/jats:sub>acts as a bidentate ligand in the formation of the dark green, crystalline oxidovanadium (IV) complex in a square pyramidal configuration. Treatment with oxidovanadium (IV)-orotate<jats:italic>in vivo<\/jats:italic>significantly improved many biochemical parameters with minimal toxicity and restored pancreatic and hepatic histology. The results of the present work describe a safe, new compound for the treatment of diabetes.<\/jats:p>","DOI":"10.1155\/2018\/8108713","type":"journal-article","created":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T23:30:55Z","timestamp":1545607855000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["A Novel Oxidovanadium (IV)-Orotate Complex as an Alternative Antidiabetic Agent: Synthesis, Characterization, and Biological Assessments"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-5239","authenticated-orcid":true,"given":"Ahmed M.","family":"Naglah","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Al-Omar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman A.","family":"Almehizia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashooq A.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid M.","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Zagazig University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma S.","family":"Al-Wasidi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan Y.","family":"Al-Humaidi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moamen S.","family":"Refat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia"},{"name":"Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(02)80018-9"},{"key":"2","year":"2005"},{"key":"3","first-page":"39","volume":"1","year":"2009","journal-title":"Der Pharmacia Lettre"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0010-8545(02)00086-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1039\/a909447d"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2005.02.026"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.10.055"},{"key":"8","year":"2018","journal-title":"Reference Module in Chemistry, Molecular Sciences and Chemical Engineering"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.05.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.10.141"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2008.06.007"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01381.x"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1016\/S0021-9258(17)30121-7","volume":"254","year":"1979","journal-title":"The Journal of Biological Chemistry"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007090708084"},{"issue":"4","key":"16","first-page":"97","volume":"61","year":"2006","journal-title":"Journal de Pharmacie de Belgique"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(90)84015-H"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90018-4"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007796515957"},{"issue":"51","key":"20","first-page":"2414","volume":"27","year":"1972","journal-title":"Das Deutsche Gesundheitswesen"},{"issue":"12","key":"21","first-page":"269","volume":"39","year":"1984","journal-title":"Zeitschrift f\u00fcr die gesamte innere Medizin und ihre Grenzgebiete"},{"key":"22","first-page":"235","volume":"42","year":"1987","journal-title":"Current Therapeutic Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66138-9"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050996"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050993"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1126\/science.119.3081.100"},{"key":"27","first-page":"11","volume":"21","year":"1974","journal-title":"Clinical Pharmacology"},{"key":"28","year":"1967"},{"key":"29","year":"1980"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(00)80009-0"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/bbpc.19850890122"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2015.01.010"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:108:1-3:185"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1080\/00387019508009895"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/201068a0"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1021\/ac60203a013"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2320\/matertrans.M2010027"},{"key":"37","year":"1978"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s007750100266"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1080\/02763860903485431"},{"key":"40","volume":"13","year":"2003"},{"issue":"1","key":"41","first-page":"57","volume":"2","year":"2011","journal-title":"Current Neurobiology"},{"issue":"7","key":"42","first-page":"317","volume":"12","year":"2002","journal-title":"The AIDS Reader"},{"key":"43","first-page":"537","volume":"50","year":"2001","journal-title":"Physiological Research"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.12.013"}],"updated-by":[{"DOI":"10.1155\/bmri\/9768273","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8108713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8108713.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8108713.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:12:10Z","timestamp":1662682330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/8108713\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,23]]},"references-count":44,"alternative-id":["8108713","8108713"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8108713","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,23]]}}}