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Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti\u2010inflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and insoluble and is a skin irritant. In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds. The cytotoxic, antioxidant, and anti\u2010inflammatory effects of EUG were assessed in human neutrophils and keratinocytes. Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG. EUG presented apparent safety and antioxidant and anti\u2010inflammatory effects on human neutrophils, but presented cytotoxic effects on keratinocytes. However, the nanocapsules were able to reduce its cytotoxicity. An <jats:italic>in vivo<\/jats:italic> experiment of irritant contact dermatitis (ICD) in mice induced by TPA showed that NCEUG reduced significantly the ear edema in mice when compared to the EUG solution, as well as the leukocyte infiltration and IL\u20106 level, possibly due to better skin permeation and irritancy blockage. These findings suggest that EUG is a promising bioactive molecule, and its nanoencapsulation seems to be an interesting approach for the treatment of ICD.<\/jats:p>","DOI":"10.1155\/2018\/8194849","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T23:31:13Z","timestamp":1544571073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti\u2010inflammatory Activities and Its Nanoformulation"],"prefix":"10.1155","volume":"2018","author":[{"given":"Amanda","family":"de Ara\u00fajo Lopes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco No\u00e9","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-7030","authenticated-orcid":false,"given":"Talita Magalh\u00e3es","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyara Barbosa","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel Vinicius Oliveira","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deysi Viviana Tenazoa","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto C\u00e9sar Pereira","family":"Lima J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-2677","authenticated-orcid":false,"given":"Luzia Kalyne Almeida Moreira","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07677-4_1"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_9"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00323-3"},{"key":"e_1_2_8_4_2","first-page":"8","article-title":"Immunocytochemical demonstration of reduced Cu,Zn-superoxide dismutase levels following topical application of dithranol and sodium lauryl sulphate: an indication of the role of oxidative stress in acute irritant contact dermatitis","volume":"1","author":"Willis C. 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