{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:01Z","timestamp":1790499541674,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comit\u00e9 de Recherche de I\u2019h\u00f4pital Habib Bourguiba, Sfax, Tunisia"},{"name":"Habib Bourguiba University hospital of Sfax"},{"name":"Ministry of High Education and Scientific Research of Tunisia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018,7,12]]},"abstract":"<jats:p>Pemphigus foliaceus (PF) is a rare autoimmune skin disease caused by anti-Dsg1 pathogenic autoantibodies. It is considered as a Th2-mediated disease. Likewise, Th17 cells were recently described in the pathogenesis of the disease but their role is still unclear. We aimed to unravel the eventual implication of the IL23\/Th17 pathway in the development of PF. A case-control study was conducted on 115 PF patients and 201 healthy controls using PCR-RFLP and AS-PCR methods. SNPs in<jats:italic>IL23R<\/jats:italic>,<jats:italic>ROR\u03b3t<\/jats:italic>,<jats:italic>IL17A<\/jats:italic>,<jats:italic>IL17F<\/jats:italic>,<jats:italic>IL17AR<\/jats:italic>,<jats:italic>TNFa<\/jats:italic>, and<jats:italic>STAT3<\/jats:italic>genes were genotyped. mRNA expression of<jats:italic>IL23R<\/jats:italic>and<jats:italic>ROR\u03b3t<\/jats:italic>was evaluated using Q-PCR. The frequency of circulating Th17 cells was analyzed by flow cytometry. Genetic associations between<jats:italic>IL23R<\/jats:italic>&gt;rs11209026,<jats:italic>IL17A<\/jats:italic>&gt;rs3748067,<jats:italic>IL17F<\/jats:italic>&gt;rs763780, and<jats:italic>TNFa<\/jats:italic>&gt;rs1800629 and the susceptibility to PF were reported. Moreover, we revealed a significant increased frequency of circulating CD4<jats:sup>+<\/jats:sup>IL17<jats:sup>+<\/jats:sup>cells as well as higher mRNA levels of ROR<jats:italic>\u03b3<\/jats:italic>t and IL23R in PBMCs of patients. However, no significant increase of ROR<jats:italic>\u03b3<\/jats:italic>t and IL23R mRNA expression was observed in lesional skin biopsies. In spite of the little size of specimens, our results provide converging arguments for the contribution of the IL23\/Th17 pathway in the pathogenesis of PF.<\/jats:p>","DOI":"10.1155\/2018\/8206983","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:05:06Z","timestamp":1531440306000},"page":"1-12","source":"Crossref","is-referenced-by-count":17,"title":["Involvement of the IL23\/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-7846","authenticated-orcid":true,"given":"M.","family":"Ben Jmaa","sequence":"first","affiliation":[{"name":"Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Abida","sequence":"additional","affiliation":[{"name":"Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, 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