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G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q is the\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -subunit of the heterotrimeric Gq protein. Researches demonstrated that G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q was involved in the pathogenesis regulation of several rheumatic diseases. This study explored the role of G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q in pSS. G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q mRNA levels in peripheral blood mononuclear cells (PBMCs) from 39 patients and 26 healthy controls (HCs) were investigated using real-time PCR. IL-17A serum concentrations in 22 pSS patients and 23 HCs were tested by ELISA, and the clinical significance of G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q was analyzed. The association of G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. We showed that G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q expression in PBMCs from patients with pSS was significantly lower than that in PBMCs from HCs. G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q expression level was closely associated with pSS disease activity. Furthermore, a negative association was also found in IL-17A and G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q expression level. These data suggest that G\n                    <jats:italic>\u03b1<\/jats:italic>\n                    q is involved in pSS pathogenesis regulation, possibly due to its regulation of Th17. These results provide new insights into the pSS pathogenesis mechanism involving abnormal Th17 regulation.\n                  <\/jats:p>","DOI":"10.1155\/2018\/8212641","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T19:35:24Z","timestamp":1528400124000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Expression of G\n                    <i>\u03b1<\/i>\n                    q Is Decreased in Lymphocytes from Primary Sj\u00f6gren\u2019s Syndrome Patients and Related to Increased IL-17A Expression"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-0363","authenticated-orcid":true,"given":"Yuechi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, 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