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This syndrome has a dramatic impact on the patient\u2019s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.<\/jats:p>","DOI":"10.1155\/2018\/8260742","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T19:42:54Z","timestamp":1540237374000},"page":"1-9","source":"Crossref","is-referenced-by-count":51,"title":["Myokines as Possible Therapeutic Targets in Cancer Cachexia"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-2611","authenticated-orcid":true,"given":"Emilia","family":"Manole","sequence":"first","affiliation":[{"name":"Molecular Biology Department, \u201cVictor Babe\u0219\u201d National Institute of Pathology, Bucharest, Romania"},{"name":"Research Center, Pathology Department, Colentina Clinical Hospital, Bucharest, 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