{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:11:59Z","timestamp":1763968319932,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC0909002"],"award-info":[{"award-number":["2017YFC0909002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,11,18]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the prevalence and risk factors of infections caused by Extended-Spectrum <jats:italic>\u03b2<\/jats:italic>-Lactamase (ESBL) producing<jats:italic> Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) in systemic lupus erythematosus (SLE) patients and develop a predictive model.<jats:italic> Methods<\/jats:italic>. Three hundred and eighty-four consecutive SLE patients with<jats:italic> E. coli<\/jats:italic> infection were enrolled in this retrospective case control study from January 2012 to December 2017. Prevalence and antimicrobial susceptibility pattern of ESBL producing<jats:italic> E. coli<\/jats:italic> were analyzed. Multivariate analysis was performed to determine the risk factors. Sensitivity and specificity were obtained at various point cutoffs and area under the receiver operator characteristic curve (AuROC) was determined to confirm the prediction power of the model.<jats:italic> Results<\/jats:italic>. Of the total 384<jats:italic> E. coli <\/jats:italic>strains tested, 212 (55.2%) produced ESBL. The majority of these isolates were from urine (44.3%). Carbapenems (&gt;80%) and amikacin (89.6%) had good activity against ESBL producing<jats:italic> E. coli<\/jats:italic>. Eleven variables were identified as independent risk factors for ESBL producing<jats:italic> E. coli <\/jats:italic>infection including Enterobacteriaceae colonization or infection in preceding year (OR=8.15, 95%CI 5.12\u201321.71), daily prednisone dose &gt; 30mg (OR=5.48, 95%CI 3.12\u201313.72), low C3 levels (OR=2.17, 95%CI 1.62\u20136.71), nosocomial acquired infection (OR=4.12, 95%CI 1.98\u20138.85), etc. The model developed to predict ESBL producing<jats:italic> E. coli<\/jats:italic> infection was effective, with the AuROC of 0.840 (95% CI 0.799-0.876).<jats:italic> Conclusions<\/jats:italic>. The prevalence of ESBL producing<jats:italic> E. coli<\/jats:italic> was increasing with high antibiotics resistance in patients with SLE. The model revealed excellent predictive performance and exhibited a good discrimination.<\/jats:p>","DOI":"10.1155\/2018\/8296720","type":"journal-article","created":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T23:38:52Z","timestamp":1542584332000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Infections Caused by Extended-Spectrum <i>\u03b2<\/i>-Lactamase Producing<i> Escherichia Coli<\/i> in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-4046","authenticated-orcid":true,"given":"Yuetian","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"},{"name":"Department of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-5536","authenticated-orcid":true,"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-6740","authenticated-orcid":true,"given":"Cheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruru","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-2914","authenticated-orcid":true,"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-6038","authenticated-orcid":true,"given":"Liangjing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313493032"},{"issue":"5","key":"2","first-page":"608","volume":"27","year":"2006","journal-title":"Saudi Medical 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