{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:31:16Z","timestamp":1788492676106,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T00:00:00Z","timestamp":1541289600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2018,11,4]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. We aimed to establish the independent predictive factors (from <jats:italic>Helicobacter pylori<\/jats:italic> infection, biliary reflux, histologic features of the gastric mucosa, drugs, comorbidities, and social habits) for gastric stump ulcer occurrence more than 15 years after surgery. <jats:italic>Methods<\/jats:italic>. 76 patients with previous gastric surgery were included: 21 patients with gastric ulcer (marginal ulcer or ulcer of the rest of the gastric remnant\u2014study group) and 55 controls (nonulcer group). <jats:italic>Results<\/jats:italic>. <jats:italic>Helicobacter pylori<\/jats:italic> infection tended to be higher in the control group than in the ulcer group (14.5% vs. 4.8%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.43<\/mml:mn><\/mml:math>), without statistical significance. Alcohol consumption had a significant positive association with ulcer (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>), while smoking (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.064<\/mml:mn><\/mml:math>), low-dose aspirin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.063<\/mml:mn><\/mml:math>), and biliary reflux (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.106<\/mml:mn><\/mml:math>) had a tendency toward statistical signification for positive association. On univariate analysis, smoking (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.048<\/mml:mn><\/mml:math>, OR\u2009=\u20093.15, 95% CI: 1.01\u20139.93) and low-dose aspirin consumption (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.067<\/mml:mn><\/mml:math>, OR\u2009=\u20092.63, 95% CI: 0.95\u20137.68) were significantly associated with ulcer. According to the multivariable regression model, alcohol consumption (OR\u2009=\u20096.68, 95% CI: 1.29\u201341.14) and biliary reflux (OR\u2009=\u20096.12, 95% CI: 1.36\u201338.26) remained significantly associated with increased odds of stump ulcer. <jats:italic>Conclusion<\/jats:italic>. Biliary reflux and alcohol consumption, but not <jats:italic>Helicobacter pylori<\/jats:italic> infection or gastrotoxic drug, seem to be the most important predictors for ulcer recurrence in patients with gastric surgery for peptic ulcer after more than 15 years.<\/jats:p>","DOI":"10.1155\/2018\/8319481","type":"journal-article","created":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T18:31:37Z","timestamp":1541356297000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Monica","family":"Pantea","sequence":"first","affiliation":[{"name":"Clinical Science-Internal Medicine, University of Medicine and Pharmacy, Gheorghe Marinescu 38, Tirgu Mure\u0219, 540139 Mures, 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