{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:56:23Z","timestamp":1789592183116,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thrombosis Research Institute, London, UK","award":["EFOP-3.6.1-16-2016-00008"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00008"]}]},{"name":"Human Resources Development Operational Programme","award":["EFOP-3.6.1-16-2016-00008"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Hyperlipidaemia model animals have been used to elucidate the role of<jats:italic>Chlamydia pneumoniae (Cpn)<\/jats:italic>infection in atherosclerosis. The aims of this study were to investigate the proatherogenic effect of multiple<jats:italic>Cpn<\/jats:italic>infections in ApoB100only\/LDLR<jats:sup>\u2212\/\u2212<\/jats:sup>mice which based on lipid profile can be regarded as the most suitable mouse model of human hypercholesterolemia and to compare the lesion development to that in a major atherosclerosis model ApoE<jats:sup>\u2212\/\u2212<\/jats:sup>mice.<jats:italic>Methods and Results<\/jats:italic>. Aorta samples of ApoB100only\/LDLR<jats:sup>\u2212\/\u2212<\/jats:sup>mice infected three times with<jats:italic>Cpn<\/jats:italic>were subjected to morphometric analyses. Morphometric evaluation disclosed that<jats:italic>Cpn<\/jats:italic>infections exacerbated atherosclerosis development in the aortic root and descending aorta of the mice fed with normal diet. Viable Cpn was detected in the ascending aorta by RT-PCR. Chlamydial 16SrRNA expression showed the presence of viable<jats:italic>Cpn<\/jats:italic>in the aorta of infected animals. A similar rate of acceleration of atherosclerosis was observed when the infection protocol was applied in ApoB100only\/LDLR<jats:sup>\u2212\/\u2212<\/jats:sup>and in ApoE<jats:sup>\u2212\/\u2212<\/jats:sup>mice.<jats:italic>Conclusion<\/jats:italic>. Similar to ApoE<jats:sup>\u2212\/\u2212<\/jats:sup>mice, ApoB100only\/LDLR<jats:sup>\u2212\/\u2212<\/jats:sup>mice with more human-relevant serum lipoprotein composition develop increased atherosclerosis after<jats:italic>Cpn<\/jats:italic>infections; thus this mouse strain can be used as a model of infection-related atherosclerosis enhancement and can provide further evidence for the proatherogenic influence of<jats:italic>Cpn<\/jats:italic>in mice.<\/jats:p>","DOI":"10.1155\/2018\/8325915","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T23:31:44Z","timestamp":1522020704000},"page":"1-12","source":"Crossref","is-referenced-by-count":9,"title":["<i>Chlamydia pneumoniae<\/i>Infection Exacerbates Atherosclerosis in ApoB100only\/LDLR<sup>\u2212\/\u2212<\/sup>Mouse 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