{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:20:05Z","timestamp":1790648405138,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T00:00:00Z","timestamp":1541289600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018,11,4]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT). <jats:italic>Objective<\/jats:italic>. The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT. <jats:italic>Materials and Methods<\/jats:italic>. Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Twenty-five were subjected to LLLT (group L), and 18 were subjected to placebo (group P). Primary outcome measure: frequency of thyroid nodules, which were subjected to fine-needle aspiration biopsy. Secondary outcome measures: dose of levothyroxine required to treat hypothyroidism, thyroid peroxidase antibodies (anti-TPO), and anti-thyroglobulin antibodies (anti-Tg). <jats:italic>Results<\/jats:italic>. In group L, a nodule was observed in three patients, who all had a Bethesda II classification. In group P, a nodule was also observed in three patients, with two classified as Bethesda II and one as Bethesda III. The levothyroxine dose required by group L was significantly lower than that required by group P (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). The anti-TPO and anti-Tg levels did not differ between the groups. <jats:italic>Conclusion<\/jats:italic>. LLLT, by the methods described, has been shown to be safe for the treatment of hypothyroidism resulting from CAT. This trial is registered with ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02240563\">NCT02240563<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2018\/8387530","type":"journal-article","created":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T18:31:39Z","timestamp":1541356299000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-663X","authenticated-orcid":true,"given":"Danilo Bianchini","family":"H\u00f6fling","sequence":"first","affiliation":[{"name":"Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Chavantes","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho, Post-Graduation, 01504-001 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Radiology Institute (InRad); Department of Radiology, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Guido","family":"Cerri","sequence":"additional","affiliation":[{"name":"Radiology Institute (InRad); Department of Radiology, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-3942","authenticated-orcid":true,"given":"Suemi","family":"Marui","sequence":"additional","affiliation":[{"name":"Thyroid Unit, Department of Endocrinology and Metabolism, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Campos","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-3079","authenticated-orcid":true,"given":"Maria Cristina","family":"Chammas","sequence":"additional","affiliation":[{"name":"Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Cl\u00ednicas, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2005.23.567"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s101030200028"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.14670\/HH-14.1067"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/php.12465"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20941"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1129-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/126720"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3716"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj1954.32.681"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/BF01733114"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.1.63"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738789"},{"key":"14","first-page":"1","volume-title":"Thyro\u00efde normale et variants","year":"2006"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4535-3"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.04.014"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2013.0002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2251011042"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2321021368"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.3.r00dc09673"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1089\/clm.1991.9.267"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0189"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0220"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-012-9192-0"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1080\/08916930410001705394"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/8387530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/8387530.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2018\/8387530.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T18:31:41Z","timestamp":1541356301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2018\/8387530\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,4]]},"references-count":27,"alternative-id":["8387530","8387530"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8387530","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,4]]}}}