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Notably, over the past 10 years, the number of<jats:italic> Clostridium difficile <\/jats:italic>outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of<jats:italic> C. difficile <\/jats:italic>strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options. Most<jats:italic> C. difficile <\/jats:italic>isolates are still susceptible to metronidazole and vancomycin. Incidences of<jats:italic> C. difficile<\/jats:italic> resistance to other antimicrobial drugs have also been reported. Most of the antibiotics correlated with<jats:italic> C. difficile<\/jats:italic> infection (CDI), such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI. Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear. Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in<jats:italic> C. difficile. <\/jats:italic>In this review, different antimicrobial agents are discussed and<jats:italic> C. difficile<\/jats:italic> resistance patterns and their mechanism of survival are summarized.<\/jats:p>","DOI":"10.1155\/2018\/8414257","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:35:46Z","timestamp":1519238146000},"page":"1-9","source":"Crossref","is-referenced-by-count":76,"title":["<i>Clostridium difficile<\/i> Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-8892","authenticated-orcid":true,"given":"Saeed S.","family":"Banawas","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah 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